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Test Details
Synonyms
- Mn, Blood
Use
Monitor manganese exposure
Limitations
In evaluating toxicity, the serum level may have returned to normal while the neurological damage persists. In evaluating possible deficiency states, the human deficiency syndrome is poorly defined, making interpretation difficult. Levels are reportedly reduced mildly in epilepsy, and raised in hepatitis or jaundice. Manganese levels are 60% lower than normal in hemodialysis patients.
Methodology
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Reference Interval
8.0−18.7 μg/L
Additional Information
Toxic exposure may occur from dry cells, fungicide (maneb), and in the steel or chemical industries. Manganese is present in the coloring agents for glass and soap, in paints, varnish and enamel, and in linoleum. It is used in the manufacture of chlorine gas and in lead-free gasoline. Industrial manganese poisoning has been recognized since 1837.
Specimen Requirements
Specimen
Whole blood
Volume
2 mL
Minimum Volume
0.6 mL
Container
Royal blue-top (EDTA) tube; submit original tube.
Collection
Submit original unopened tube.
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Causes for Rejection
Royal blue-top tube not submitted
Clinical Information
References
Ferraz HB, Bertolucci PH, Pereira JS, et al. chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology. 1988; 38(4):550-553. 3352909
Kondakis XG, Makris N, Leotsinidis M, et al. Possible health effects of high manganese concentration in drinking water. Arch Environ Health. 1989; 44(3):175-178. 2751354