Manganese, Whole Blood

CPT: 83785
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Test Details

Synonyms

  • Mn, Blood

Use

Monitor manganese exposure

Limitations

In evaluating toxicity, the serum level may have returned to normal while the neurological damage persists. In evaluating possible deficiency states, the human deficiency syndrome is poorly defined, making interpretation difficult. Levels are reportedly reduced mildly in epilepsy, and raised in hepatitis or jaundice. Manganese levels are 60% lower than normal in hemodialysis patients.

Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)

Reference Interval

8.0−18.7 μg/L

Additional Information

Toxic exposure may occur from dry cells, fungicide (maneb), and in the steel or chemical industries. Manganese is present in the coloring agents for glass and soap, in paints, varnish and enamel, and in linoleum. It is used in the manufacture of chlorine gas and in lead-free gasoline. Industrial manganese poisoning has been recognized since 1837.

Specimen Requirements

Specimen

Whole blood

Volume

2 mL

Minimum Volume

0.6 mL

Container

Royal blue-top (EDTA) tube; submit original tube.

Collection

Submit original unopened tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

7 days

Causes for Rejection

Royal blue-top tube not submitted

Clinical Information

References

Ferraz HB, Bertolucci PH, Pereira JS, et al. chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology. 1988; 38(4):550-553. 3352909
Kondakis XG, Makris N, Leotsinidis M, et al. Possible health effects of high manganese concentration in drinking water. Arch Environ Health. 1989; 44(3):175-178. 2751354

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
724195 Manganese, Blood 5681-2 724196 Manganese, Blood ug/L 5681-2

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