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A random urine calcium:creatinine ratio is used to screen for hypercalciuria, as it is found to have a good correlation with 24-hour urine calcium excretion.1 Increased urinary excretion of calcium accompanies hyperparathyroidism, vitamin D intoxication, diseases that destroy bone (such as multiple myeloma), metastasis from prostatic cancer, and following calcium supplementation. Urine calcium is increased with immobilization, with steroid therapy, with Paget disease, and in primary (idiopathic) hypercalciuria.
Collect urine and transfer to a random urine transport tube or urine Monovette® with pH stabilizer (LabCorp N° 56015). Final pH must be <2.
After collection, pH is adjusted to 1.5−2.0 with 6N HCl. Refrigerate.
Causes for Rejection
Improperly labeled specimen
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|134908||Calcium/Creatinine Ratio||013490||Calcium, Urine||mg/dL||18488-7|
|134908||Calcium/Creatinine Ratio||013672||Creatinine, Urine||mg/dL||2161-8|
|134908||Calcium/Creatinine Ratio||134911||Calcium/Creat.Ratio||mg/g creat||9321-1|