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Hepatitis B Virus (HBV)

Early and comprehensive HBV testing is critical to identify infected individuals, monitor disease progression, and enable timely intervention to reduce long-term morbidity and mortality.
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Why Hepatitis B testing matters

~2.4M Americans are living with chronic Hepatitis B (HBV) infection, yet only about one-third have been diagnosed, leaving many unaware of their risk for serious liver complications.¹
14% Acute HBV infections increased by 14% between 2015 and 2019², underscoring ongoing transmission and missed prevention opportunities.
>40,000 Chronic HBV is also a major driver of liver cancer, contributing to more than 40,000 liver cancer cases annually in the United States.³

New CDC Hepatitis B virus screening guidance4

The CDC recommends expanded Hepatitis B screening using the triple panel, which includes HBsAg, anti-HBs, and total anti-HBc, to improve detection of active infection, resolved infection, and immunity.

  • Screen all adults aged 18 years and older at least once in their lifetime using the HBV triple panel (HBsAg, anti-HBs, total anti-HBc)

  • Screen all pregnant women during each pregnancy, typically with HBsAg testing, with triple-panel testing if prior HBV status is unknown

  • Repeat screening for individuals with ongoing risk factors or higher risk of exposure, including people born in regions with higher Hepatitis B prevalence, people who inject drugs, men who have sex with men, individuals with HIV infection, patients receiving hemodialysis, and household or sexual contacts of persons with Hepatitis B

Additional Hepatitis B testing options

Hepatitis B Surface Antigen (HBsAg) Screen, Qualitative With Reflex to Hepatitis D Virus (HDV) Antibody [006514] Hepatitis B Virus (HBV), Quantitative, DNA Real-time PCR, (Nongraphical)[551610] Hepatitis B Virus (HBV), Quantitative, DNA Real-time PCR, (Graphical) [551620] Hepatitis B Virus (HBV) DNA, Quantitative Real-time PCR With Reflex to HBV Genotype [551722] Hepatitis B Virus (HBV) DNA, Quantitative Real-time PCR With Reflex to HBV Genotype Plus Drug Resistance [551735] Hepatitis B Virus (HBV) Genotype [551710] Hepatitis B Virus (HBV) Genotyping Plus Drug Resistance [551750]

Why partner with Labcorp

Clinical support for hepatitis care

Labcorp offers guideline-aligned hepatitis testing panels designed to support appropriate screening, diagnosis, and disease monitoring. Automated reflex testing pathways help streamline the diagnostic process by advancing patients from screening to confirmatory testing without requiring additional provider orders. With broad national access and expert interpretive support, clinicians receive clear and actionable insights to guide patient management.

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Streamlined testing workflows

Labcorp simplifies hepatitis testing workflows through efficient ordering processes and integrated electronic health record connectivity. These capabilities reduce administrative burden for clinical staff while enabling timely result reporting. A nationwide network of patient service centers ensures convenient specimen collection and consistent access to testing.

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Supporting population health

Comprehensive hepatitis testing solutions help health systems expand screening programs and support population health initiatives. Earlier detection and prompt linkage to care facilitate more timely intervention, which may help reduce progression to advanced liver disease and long-term 

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Questions about our Hepatitis B portfolio?

References

  1. CDC – Viral Hepatitis Surveillance (2022) - https://www.cdc.gov/hepatitis/statistics/2022surveillance/index.htm
  2. CDC – Viral Hepatitis Surveillance (2019–2020) https://www.cdc.gov/hepatitis/statistics/2019surveillance/index.htm
  3. AASLD – Hepatitis B Treatment Guidance - https://www.aasld.org/practice-guidelines/hepatitis-b
  4. CDC – Hepatitis B Screening Guidelines (2023) - https://www.cdc.gov/mmwr/volumes/72/rr/rr7201a1.htm
  5. Patel EU et al. – U.S. HDV Prevalence (Journal of Infectious Diseases) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439036/
  6. AASLD – Hepatitis D Diagnosis & Management - https://www.aasld.org/liver-fellow-network/core-series/clinical-pearls/hepatitis-d-diagnosis-and-management