Methylphenidate, Serum or Plasma

CPT: 80360
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  • Ritalin®

Expected Turnaround Time

5 days

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Specimen Requirements


Serum or plasma


2 mL

Minimum Volume

0.5 mL


Red-top (no additive) tube or green-top (heparin) tube; gel-barrier tubes not recommended


Transfer separated serum or plasma to a plastic transport tube. Collection time: Peak levels occur at 1-3 hours post dose; trough levels often not.

Storage Instructions

Submission/transport/storage: Freeze.

Stability Requirements

• Room temperature: Unstable

• Refrigerated: Unstable

• Frozen: 14 days

Causes for Rejection

Specimen received unfrozen

Test Details


Therapeutic drug management


This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Therapeutic: 5.0−20.0 ng/mL


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
715300 Methylphenidate, Serum 3807-5 715301 Methylphenidate, S ng/mL 3807-5

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