Amino Acid Profile, Quantitative, Plasma

CPT: 82139
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Expected Turnaround Time

3 - 6 days


Related Information


Related Documents


Specimen Requirements


Specimen

Plasma, frozen


Volume

0.5 mL


Minimum Volume

0.15 mL (Note: This volume does not allow for repeat testing.)


Container

Preferred: Frozen plasma from green-top (sodium heparin) tube. Acceptable: Frozen plasma from green-top (lithium heparin) tube, frozen plasma from lavender-top (EDTA) tube or frozen plasma from PPT™. Frozen serum from serum separator tube (SST) or frozen serum from red-top tube will not be rejected. Note: Plasma reference ranges will be applied to all specimen types.


Collection

Separate plasma from cells. Transfer specimen to plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Centrifuge, remove plasma from cells, and freeze immediately.


Stability Requirements

Temperature

Period

Room temperature

Unstable

Refrigerated

Unstable

Frozen

14 days


Causes for Rejection

Gross hemolysis; room temperature or thawed specimen; specimens collected in yellow-top (ACD) tubes


Test Details


Use

Diagnosis and monitoring of inherited aminoacidurias, organic acidurias, and urea cycle defects. May be used as a follow-up confirmatory test to some abnormal newborn screen results.


Limitations

False-negative results can occur, especially when a patient is affected with a mild or intermittent variant of a disorder or when clinical condition or dietary treatment causes secondary changes to the profile. Results of amino acid profiling should be interpreted in the context of clinical presentation, as well as other laboratory tests. Frozen serum may be diagnostic, however, certain amino acids may be falsely elevated or low.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Reference Interval

See Plasma Amino Acid Reference Intervals in the Test Resources pages online.


References

Bremer HJ, Duran M, Kamerling JP, et al. Disturbances of Amino Acid Metabolism: Clinical Chemistry and Diagnosis. Baltimore, Md: Urban and Schwarzenberg; 1981.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
700068 Amino Acid Profile, Qn, Plasma 35083-5 700007 Taurine umol/L 20657-3
700068 Amino Acid Profile, Qn, Plasma 35083-5 700008 Aspartate umol/L 20639-1
700068 Amino Acid Profile, Qn, Plasma 35083-5 700009 Hydroxyproline umol/L 20647-4
700068 Amino Acid Profile, Qn, Plasma 35083-5 700010 Threonine umol/L 20658-1
700068 Amino Acid Profile, Qn, Plasma 35083-5 700011 Serine umol/L 20656-5
700068 Amino Acid Profile, Qn, Plasma 35083-5 700012 Asparagine umol/L 20638-3
700068 Amino Acid Profile, Qn, Plasma 35083-5 700014 Glutamate umol/L 20642-5
700068 Amino Acid Profile, Qn, Plasma 35083-5 700015 Glutamine umol/L 20643-3
700068 Amino Acid Profile, Qn, Plasma 35083-5 700016 Sarcosine umol/L 26613-0
700068 Amino Acid Profile, Qn, Plasma 35083-5 700017 Alpha-aminoadipate umol/L 26600-7
700068 Amino Acid Profile, Qn, Plasma 35083-5 700018 Proline umol/L 20655-7
700068 Amino Acid Profile, Qn, Plasma 35083-5 700019 Glycine umol/L 20644-1
700068 Amino Acid Profile, Qn, Plasma 35083-5 700020 Alanine umol/L 20636-7
700068 Amino Acid Profile, Qn, Plasma 35083-5 700022 Citrulline umol/L 20640-9
700068 Amino Acid Profile, Qn, Plasma 35083-5 700023 Alpha-aminobutyrate umol/L 20634-2
700068 Amino Acid Profile, Qn, Plasma 35083-5 700024 Valine umol/L 20661-5
700068 Amino Acid Profile, Qn, Plasma 35083-5 700025 Cystine umol/L 22672-0
700068 Amino Acid Profile, Qn, Plasma 35083-5 700026 Methionine umol/L 20651-6
700068 Amino Acid Profile, Qn, Plasma 35083-5 700027 Homocitrulline umol/L 55876-7
700068 Amino Acid Profile, Qn, Plasma 35083-5 700028 Cystathionine umol/L 26607-2
700068 Amino Acid Profile, Qn, Plasma 35083-5 700029 Alloisoleucine umol/L 22670-4
700068 Amino Acid Profile, Qn, Plasma 35083-5 700030 Isoleucine umol/L 20648-2
700068 Amino Acid Profile, Qn, Plasma 35083-5 700031 Leucine umol/L 20649-0
700068 Amino Acid Profile, Qn, Plasma 35083-5 700032 Tyrosine umol/L 20660-7
700068 Amino Acid Profile, Qn, Plasma 35083-5 700033 Phenylalanine umol/L 14875-9
700068 Amino Acid Profile, Qn, Plasma 35083-5 700034 Argininosuccinate umol/L 32227-1
700068 Amino Acid Profile, Qn, Plasma 35083-5 700035 Beta-alanine umol/L 26604-9
700068 Amino Acid Profile, Qn, Plasma 35083-5 700036 Beta-aminoisobutyrate umol/L 26605-6
700068 Amino Acid Profile, Qn, Plasma 35083-5 700037 Homocystine umol/L 20646-6
700068 Amino Acid Profile, Qn, Plasma 35083-5 700038 Gamma-aminobutyrate umol/L 26609-8
700068 Amino Acid Profile, Qn, Plasma 35083-5 700040 Tryptophan umol/L 20659-9
700068 Amino Acid Profile, Qn, Plasma 35083-5 700041 Hydroxylysine umol/L 26610-6
700068 Amino Acid Profile, Qn, Plasma 35083-5 700042 Ornithine umol/L 20652-4
700068 Amino Acid Profile, Qn, Plasma 35083-5 700043 Lysine umol/L 20650-8
700068 Amino Acid Profile, Qn, Plasma 35083-5 700044 Histidine umol/L 20645-8
700068 Amino Acid Profile, Qn, Plasma 35083-5 700045 Arginine umol/L 20637-5
700068 Amino Acid Profile, Qn, Plasma 35083-5 700063 Interpretation 49247-0
700068 Amino Acid Profile, Qn, Plasma 35083-5 700064 Director Review 72486-4
700068 Amino Acid Profile, Qn, Plasma 35083-5 700065 Methodology 49549-9

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