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Anti-Dense Fine Speckled Protein 70 kDa (DFS70) Ab

CPT: 83516

Synonyms

  • Anti-dense fine speckled
  • DFS70/LEDGFp75
  • LEDGFp75
  • Lens Epithelium-derived Growth Factor or transcription co-activator p75
  • SARD exclusion marker

Special Instructions

This test has not been approved for NY state clients.


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL


Container

Red-top tube; serum from red-top tube; serum from a gel tube; or serum gel tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Anti-DFS70 antibodies may help identify individuals who do not have an ANA-associated Autoimmune Rheumatic Disease (AARD) especially in the absence of significant clinical findings.1 Anti-DFS70 Ab, especially when positive in isolation (i.e. in the absence of AARD-associated autoantibodies), may prevent unnecessary referrals and examinations of ANA-positive individuals.2


Limitations

This test should be used with clinical findings and other autoimmune testing; it cannot be used alone to rule out autoimmune disease.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


Additional Information

Anti-DFS70 antibodies target the dense fine speckled protein of 70 kDa which is identical to Lens Epithelium-Derived Growth Factor or transcription co-activator p75 (LEDGFp75). They are detectable in 2% to 22% of healthy individuals and in less than 1% of patients with AARD are of unknown clinical significance.


Footnotes

1. Conrad K, Röber N, Andrade LEC, Mahler M. The Clinical Relevance of Anti-DFS70 Autoantibodies. Clin Rev Allergy Immunol. 2017 Apr;52(2):202-216.27350273
2. Fitch-Rogalsky C, Steber W, Mahler M, et al. Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies. PLoS One. 2014 Apr 4;9(4):e93812.24705829

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