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Anti-Dense Fine Speckled Protein 70 kDa (DFS70) Ab

CPT: 83516
Updated on 09/14/2021
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  • Anti-dense fine speckled
  • DFS70/LEDGFp75
  • LEDGFp75
  • Lens Epithelium-derived Growth Factor or transcription co-activator p75
  • SARD exclusion marker

Special Instructions

This test has not been approved for NY state clients.

Specimen Requirements




1 mL

Minimum Volume

0.5 mL


Red-top tube; serum from red-top tube; serum from a gel tube; or serum gel tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Test Details


Anti-DFS70 antibodies may help identify individuals who do not have an ANA-associated Autoimmune Rheumatic Disease (AARD) especially in the absence of significant clinical findings.1 Anti-DFS70 Ab, especially when positive in isolation (i.e. in the absence of AARD-associated autoantibodies), may prevent unnecessary referrals and examinations of ANA-positive individuals.2


This test should be used with clinical findings and other autoimmune testing; it cannot be used alone to rule out autoimmune disease.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Enzyme-linked immunosorbent assay (ELISA)

Additional Information

Anti-DFS70 antibodies target the dense fine speckled protein of 70 kDa which is identical to Lens Epithelium-Derived Growth Factor or transcription co-activator p75 (LEDGFp75). They are detectable in 2% to 22% of healthy individuals and in less than 1% of patients with AARD are of unknown clinical significance.


1. Conrad K, Röber N, Andrade LEC, Mahler M. The Clinical Relevance of Anti-DFS70 Autoantibodies. Clin Rev Allergy Immunol. 2017 Apr;52(2):202-216.27350273
2. Fitch-Rogalsky C, Steber W, Mahler M, et al. Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies. PLoS One. 2014 Apr 4;9(4):e93812.24705829


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520313 Anti-DFS70 Ab 95129-3 520314 Anti-DFS70 Ab Units 95129-3

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