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Vasculitis Profile (RDL)

CPT: 83516(x3); 86038; 86160(x2); 86225; 86255; 86431
83520(x3); 86038; 86160(x2); 86225; 86255; 86431
83516(x3); 86038; 86160(x2); 86225; 86255; 86431
Updated on 10/12/2021
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Expected Turnaround Time

10 days


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Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types


Test Details


Use

ANA are commonly found in a variety of autoimmune diseases. Antibody frequency increases with age in apparently healthy people. ANA patterns on HEp-2 slides provide only general clues about particles (chromatin, nucleosomes, and spliceosomes).

The Farr assay is the most specific method of detecting dsDNA autoantibodies. Significant elevations in dsDNA autoantibody concentrations confirm the diagnosis of systemic lupus erythematosus (SLE). Serial studies of elevated values of dsDNA auto antibodies are useful for predicting activity of SLE.

Anti-MPO autoantibodies aid in assessment of certain autoimmune vasculitides such as microscopic polyarteritis, and crescentic glomerulonephritis. PR-3 is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) that give a cytoplasmic (C-ANCA) autoantibodies (ANCA) which give a perinuclear (pANCA) immunofluorescence pattern.

Anti-PR-3 autoantibodies aid in the assessment of certain autoimmune vasculitides such as microscopic polyartheritis and crescentic glomerulonephritis. PR-3 is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) that give a cytoplasmic (C-ANCA) immunofluorescence pattern. Elevated levels of Anti-PR-3 are classically observed in patients with Wegener granulomatosis (WG), particularly with active disease, and less frequently in other forms of necrotizing vasculitis.

ANTI-GBM autoantibodies are recognized as being important in the pathogenesis of the rapidly progressive glomerulonephritis of Goodpasture's syndrome. Measurements of C3 and C4 are used to detect individuals with inborn deficiency of this factor or those with immunologic disease in whom complement is consumed at an increased rate. These include lupus erythematosus, chronic active hepatitis, certain chronic infections, poststreptococcal and membranoproliferative glomerulonephritis, and others.


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

See individual test components.


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520293 Vasculitis Profile (RDL) 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520293 Vasculitis Profile (RDL) 520071 ANCA by IFA (RDL) 35279-9
520293 Vasculitis Profile (RDL) 520215 Anti-PR-3 Ab (RDL) Units 46267-1
520293 Vasculitis Profile (RDL) 520154 Anti-MPO Ab (RDL) Units 72515-0
520293 Vasculitis Profile (RDL) 520249 Anti-GBM Ab (RDL) Units 31406-2
520293 Vasculitis Profile (RDL) 520132 Rheumatoid Factor by Turb RDL IU/mL 11572-5
520293 Vasculitis Profile (RDL) 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520293 Vasculitis Profile (RDL) 520169 C3 Complement (RDL) mg/dL 4485-9
520293 Vasculitis Profile (RDL) 520167 C4 Complement (RDL) mg/dL 4498-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 54151-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf