Anti-Synthetase Profile (RDL)

CPT: 83516(x4); 86235
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Test Includes

Anti-EJ Ab; Anti-Jo-1 Ab; Anti-OJ Ab; Anti-PL-7 Ab, Anti-PL-12 Ab

Expected Turnaround Time

14 - 21 days

Related Documents

Specimen Requirements




3 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


This Anti-Synthetase Profile is comprised of Anti-Jo-1 Ab, Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab and Anti-OJ Ab. Anti-synthetase syndrome is an autoimmune disease characterized by interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever and/or mechanic’s hands.1


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


RIPA gel radiography, Enzyme-linked immunosorbent assay (ELISA)


1. Witt LJ, Curran JJ, Strek ME. The diagnosis and treatment of antisynthetase syndrome. Clin Pulm Med. 2016 Sep;23(5):218-226.27594777


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520193 Anti-Synthetase Profile (RDL) Pending 520259 Anti-Jo-1 Ab (RDL) Units 35333-4
520193 Anti-Synthetase Profile (RDL) Pending 520046 Anti-PL-7 Ab (RDL) 33772-5
520193 Anti-Synthetase Profile (RDL) Pending 520049 Anti-PL-12 Ab (RDL) 33771-7
520193 Anti-Synthetase Profile (RDL) Pending 520027 Anti-EJ Ab (RDL) 45149-2
520193 Anti-Synthetase Profile (RDL) Pending 520029 Anti-OJ Ab (RDL) 45152-6

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