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ANA Profile 12 (RDL)

CPT: 86038
Updated on 09/23/2020
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Synonyms

  • ANA 12
  • ANA 12 Panel

Test Includes

ANA Profile 12 is reflexive and is comprised of Anti-Nuclear Ab (ANA) by IFA, Anti-Cardiolipin Ab (IgG, IgA & IgM Isotypes), Anti-Centromere Ab, Anti-dsDNA Ab by Farr, Anti-La (SS-B) Ab, Anti-Ro (SSA) Ab, Anti-Scl-70 Ab, Anti- Sm, Anti-TPO (Thyroid Microsomal Peroxidase) Ab, Anti-U1 RNP, C3 Complement, C4 Complement.

If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) test is performed to catch the small percentage of ANA false negative results. ANA includes titer & pattern.


Expected Turnaround Time

14 - 21 days


Specimen Requirements


Specimen

Serum


Volume

5 mL

4 mL

5 mL


Minimum Volume

4 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.


Storage Instructions

Refrigerate.

Refrigerate.

Refrigerate.

Refrigerate.

Refrigerate.


Stability Requirements

Temperature

Period

Room temperature

8 days

Refrigerated

8 days

Frozen

8 days


Causes for Rejection

Grossly hemolyzed, bacterial contamination, lipemic, icteric, non-serum specimen types


Test Details


Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti-dsDNA by Farr

• Anti-SM

Tests with moderate specificity

• Anti-Ro

• Anti-La

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Sjogren’s Syndrome

• Anti-Ro

• Anti-La

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centromere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

ELISA, IFA, Farr RIA,CMIA


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520188 ANA Profile 12 (RDL) 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520066 Anti-Centromere Ab (RDL) 5077-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520216 Anti-Sm Ab (RDL) Units 11090-8
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
Reflex 3 520043 Confirmatory Anti Scl-70 520043 Confirmatory Anti Scl-70 8292-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520169 C3 Complement (RDL) mg/dL 4485-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520167 C4 Complement (RDL) mg/dL 4498-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 2 520177 ANA 12 Profile, Positive Ro 520229 ANA 12 Profile Interpretation N/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520074 Homogeneous Pattern 20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520076 Nucleolar Pattern 20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520233 Speckled Pattern 20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520234 Centromere Pattern 53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520235 Spindle Apparatus Pattern 53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520236 Nuclear Membrane Pattern 54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520237 Midbody Pattern 54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520238 Nuclear Dot Pattern 53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520239 PCNA Pattern 53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520240 Centriole Pattern 54151-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520241 Note: 77202-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520066 Anti-Centromere Ab (RDL) 5077-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520216 Anti-Sm Ab (RDL) Units 11090-8
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
Reflex 2 520043 Confirmatory Anti Scl-70 520043 Confirmatory Anti Scl-70 8292-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520169 C3 Complement (RDL) mg/dL 4485-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520167 C4 Complement (RDL) mg/dL 4498-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520229 ANA 12 Profile Interpretation N/A

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