LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.
ANA Profile 12 is reflexive and is comprised of Anti-Nuclear Ab (ANA) by IFA, Anti-Cardiolipin Ab (IgG, IgA & IgM Isotypes), Anti-Centromere Ab, Anti-dsDNA Ab by Farr, Anti-La (SS-B) Ab, Anti-Ro (SSA) Ab, Anti-Scl-70 Ab, Anti- Sm, Anti-TPO (Thyroid Microsomal Peroxidase) Ab, Anti-U1 RNP, C3 Complement, C4 Complement.
If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) test is performed to catch the small percentage of ANA false negative results. ANA includes titer & pattern.
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
3 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Separate serum from cells within one hour
Separate serum from cells within one houring.
Grossly hemolyzed, bacterial contamination, lipemic, icteric, non-serum specimen types
The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.
RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:
• ANA by IFA
Tests with high specificity
• Anti-dsDNA by Farr
Tests with moderate specificity
• C3 & C4 Complements
• Anticardiolipin IgG, IgA & IgM
Mixed Connective Tissue Disease (MCTD)
• Anti-U1 RNP
Limited Scleroderma (CREST)
• Anti-SCL-70 by EIA, confirmed by ID
Autoimmune Thyroid Disease
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
ELISA, IFA, Farr RIA,CMIA
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