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This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes), Anti‐TPO (Thyroid Microsomal Peroxidase) Ab, Anti‐Chromatin Ab, Rheumatoid Factor by Turb, Anti‐CCP (Cyclic Citrullinated Peptide) Ab.
The reflexive ANA 12 Plus Profile is a separate test (use 520180).
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
1.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Refrigerate or freeze.
Grossly hemolyzed, bacterial contamination, lipemic, icteric, non‐serum specimen types
The ANA test detects autoantibodies that bind to the nuclear components of HEp‐2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic andpotential prognostic utility for several autoimmune diseases.
RDL’s ANA 12 Plus Profile Helps Differentiate Between 8 Autoimmune Disease States:
• ANA by IFA
Tests with high specificity
• Anti‐dsDNA by Farr
Tests with moderate specificity
• C3 & C4 Complements
• Anticardiolipin IgG, IgA & IgM
• Anti‐CCP (high specificity)
• Rheumatoid Factor (Turbidimetry)
Mixed Connective Tissue Disease (MCTD)
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
ELISA, IFA, Farr RIA, Turbidimetry, CMIA
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