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Anti-U2 RNP Ab (RDL)

CPT: 86235
Updated on 09/23/2020
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  • Anti-U2 small nuclear ribonucleoprotein (snRNP)
  • snRNP
  • U2

Expected Turnaround Time

14 - 21 days

7 - 14 days

14 - 21 days

Specimen Requirements




1 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


U2 snRNP autoantibodies, known as a type of myositis-associated autoantibodies (MSAs) are frequently, but not exclusively, in patients with myositis. MSAs include autoantibodies to U1-RNP, U2-RNP, PM/SCL and Ku.


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


RIPA Gel Radiography

Reference Interval


Additional Information

<5% of IIM; scleroderma/myositis overlap syndrome


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520024 Anti-U2 RNP Ab (RDL) 68549-5 520025 Anti-U2 RNP Ab (RDL) 68549-5

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