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Anti-SAE1 Ab, IgG (RDL)

CPT: 83520

Synonyms

  • SAE Ab; small ubiquitin-like modifier activating enzyme

Test Includes

This test is a component of MyoMarker 3 Plus Profile.


Expected Turnaround Time

7 - 14 days


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Container

Gel tube or red-top tube


Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.


Storage Instructions

Refrigerate or freeze.


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1


Causes for Rejection

Grossly hemolyzed, bacterial contamination, lipemic, icteric, non-serum specimen types


Test Details


Use

Anti-SAE 1 IgG autoantibody can be used to assist in the diagnoses and characterization of a subset of dermatomyositis (DM). It is highly specific for DM (>95%) and is present in 5-8% of the European DM population. Initial disease onset may consist of mild myopathic features with severe skin involvement; however, extensive myalgia and muscle disease with weakness can appear as the disease progresses. It is associated with dysphagia and systemic symptoms (i.e. fevers, weight loss, increased inflammatory markers). In one cohort, an association with ILD and cancer had been found.


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf