Anti-CCP (Cyclic Citrullinated Peptide) Antibodies, IgG and IgA (RDL)

CPT: 86200
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  • Anti-Cyclic Citrullinated Peptide Ab
  • CCP
  • Cyclic Citrullinated Peptide Antibody

Expected Turnaround Time

5 - 7 days

Specimen Requirements




1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Refrigerate or freeze.

Stability Requirements



Room temperature

7 days


14 days


60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details


Anti-CCP (cyclic citrullinated peptide) antibodies are autoantibodies present in established rheumatoid arthritis (RA) (sensitivity 66-79%) and early RA (sensitivity 59%).1,2 In addition, Anti-CCP is more specific than RF diagnosis (specificity 90-96%).1,3


This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Enzyme-linked immunosorbent assay (ELISA)


1. Lee DM, Schur PH. Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann Rheum Dis. 2003 Sep;62(9):870-874.12922961
2. Maksymowych WP, Naides SJ, Bykerk V, et al. Serum 14-3-3 eta is a novel marker that complements current serological measurements to enhance detection of patient with rheumatoid arthritis. J Rheumatol. 2014 Nov;41(11):2104-2113.25128504
3. Dubucquoi S, Solau-Gervais E, Lefranc D, et al. Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases. Ann Rheum Dis. 2004 Apr;63(4):415-419.15020336


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520008 Anti-CCP Ab, IgG + IgA (RDL) 57093-7 520047 Anti-CCP Ab, IgG + IgA (RDL) Units 57093-7

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