Chromosome Five-cell Count Plus Microarray (Reveal®), Amniotic Fluid

CPT: 81229; 88235; 88261; 88280
81229; 88235; 88261; 8828081229; 88235; 88261; 88280
81229; 88235; 88261; 8828081229; 88235; 88261; 88280
Updated on 03/28/2024
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  • Amniotic Fluid Chromosome Five-cell Count Plus Microarray

Test Includes

DNA extraction; interpretation; limited five-cell amniotic sample chromosome analysis (two analyses, one karyotype)

Special Instructions

A completed Clinical Questionnaire for SNP Microarray should accompany specimens. Call 800-345-4363 to request the appropriate form, or photocopy the form from the Genetics Appendix online.

Concurrent maternal contamination (MCC) studies are required.

If prior NIPT studies have been performed, include copy of the report.

If specimens from a twin pregnancy are submitted by request it can be reported if these are DZ or MZ twins.

Expected Turnaround Time

10 - 12 days

Specimen Requirements


Amniotic fluid (for direct array and abbreviated amnio chromosome analysis)

Gender by ultrasound is required. Please submit maternal blood (sodium heparin or EDTA) for maternal cell contamination (MCC) studies.

If the specimen does not meet minimum DNA quality and quantity requirements, array testing will be performed on cultured material. If cultures are needed, additional days will be required to complete testing. A notification will be sent to the client if cultures are necessary.


25 mL amniotic fluid for concurrent array and chromosome analysis

Minimum Volume

12 mL amniotic fluid (minimum volume may delay results; cells would need to be cultured for microarray analysis)


Sterile plastic conical tube


Discard first 2 mL of fluid aspirated to avoid maternal cell contamination. Specimen is collected in a 20-mL sterile syringe and transferred aseptically to sterile tubes to be transported to LabCorp.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Quantity not sufficient for analysis (<12 mL of amniotic fluid or DNA quantity <20 ng/μL); bloody sample; gestational age <17 weeks

Test Details


The test allows prenatal detection of chromosomal aneuploidy, and is used to rule out tetraploidy and rearrangements not detected by array, such as balanced translocations and inversions. It also helps to clarify array abnormalities to determine if a structural rearrangement, marker, or isochromosome is present. Array can only provide copy number imbalances and cannot determine structure of an abnormality. The SNP assay will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent.


This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Five-cell G-Band Chromosome analysis. SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.


Coppinger J, Alliman S, Lamb AN, et al. Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray. Prenat Diagn. 2009 Dec; 29(12):1156-1166. 19795450
Wapner R. A multicenter, prospective, masked comparison of chromosomal microarray with standard karyotyping for routine and higher risk prenatal diagnosis. Am J Ob Gyn. 2012 Jan; (Suppl). Abstract 1.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511590 Amnio Chrom 5 Cnt + CMA 052182 Cells Counted 64095-3
511590 Amnio Chrom 5 Cnt + CMA 052184 Colonies 64096-1
511590 Amnio Chrom 5 Cnt + CMA 052185 Cells Analyzed 64092-0
511590 Amnio Chrom 5 Cnt + CMA 052186 Cells Karyotyped 64091-2
511590 Amnio Chrom 5 Cnt + CMA 052187 GTG Band Resolution Achieved 64093-8
511590 Amnio Chrom 5 Cnt + CMA 052188 Cytogenetic Diagnosis 33773-3
511590 Amnio Chrom 5 Cnt + CMA 052037 Cytogenetic Interpretation 64094-6
511590 Amnio Chrom 5 Cnt + CMA 052191 Specimen Type 31208-2
511590 Amnio Chrom 5 Cnt + CMA 052038 Director Review: 48672-0
511590 Amnio Chrom 5 Cnt + CMA 512123 PDF 51967-8
511590 Amnio Chrom 5 Cnt + CMA 510103 Specimen Type 31208-2
511590 Amnio Chrom 5 Cnt + CMA 510104 # of Genotyping Targets N/A
511590 Amnio Chrom 5 Cnt + CMA 510105 Array Type N/A
511590 Amnio Chrom 5 Cnt + CMA 510106 Diagnosis 48000-4
511590 Amnio Chrom 5 Cnt + CMA 510107 Interpretation 62365-2
511590 Amnio Chrom 5 Cnt + CMA 510108 Director Review 48672-0

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