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Myelodysplastic Syndrome (MDS), FISH

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Test Includes

Fluorescence in situ hybridization (FISH) for myelodysplastic syndrome (MDS), targeting numerical changes associated with 5q, 7q, 8, and 20q.


Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form.


Expected Turnaround Time

3 - 5 days



Related Documents


Specimen Requirements


Specimen

Blood, bone marrow, fixed-cell pellet from a cytogenetic analysis, or slides prepared from a cytogenetic analysis


Volume

10 mL blood (adult), 3 to 5 mL blood (pediatric), 1 to 3 mL bone marrow, one fixed-cell pellet, or four slides


Minimum Volume

1 mL blood (adult/pediatric), 1 mL bone marrow, or four slides


Container

Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Storage Instructions

Maintain specimen at room temperature.


Causes for Rejection

Broken Vacutainer®; broken slides


Test Details


Use

Diagnostic test for myelodysplastic syndrome. The principal use is for interphase analysis of cases with no (or low) mitotic activity in cytogenetic analysis or interphase analysis from blood in cases of inaspirable bone marrow. Detection rate is approximately 80% of clones detected in cytogenetic analysis.


Methodology

Fluorescence in situ Hybridization (FISH)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511060 MDS FISH Panel 510616 Cells Counted 62361-1
511060 MDS FISH Panel 510617 Cells Analyzed 62360-3
511060 MDS FISH Panel 510618 FISH Result 57802-1
511060 MDS FISH Panel 511042 Interpretation 50398-7
511060 MDS FISH Panel 510620 Specimen Type 31208-2
511060 MDS FISH Panel 511038 Director Review: 48672-0

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf