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Myelodysplastic Syndrome (MDS), FISH

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Test Includes

Fluorescence in situ hybridization (FISH) for myelodysplastic syndrome (MDS), targeting numerical changes associated with 5q, 7q, 8, and 20q.

Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form.

Expected Turnaround Time

3 - 5 days

Related Documents

Specimen Requirements


Blood, bone marrow, fixed-cell pellet from a cytogenetic analysis, or slides prepared from a cytogenetic analysis


10 mL blood (adult), 3 to 5 mL blood (pediatric), 1 to 3 mL bone marrow, one fixed-cell pellet, or four slides

Minimum Volume

1 mL blood (adult/pediatric), 1 mL bone marrow, or four slides


Green-top (heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken Vacutainer®; broken slides

Test Details


Diagnostic test for myelodysplastic syndrome. The principal use is for interphase analysis of cases with no (or low) mitotic activity in cytogenetic analysis or interphase analysis from blood in cases of inaspirable bone marrow. Detection rate is approximately 80% of clones detected in cytogenetic analysis.


Fluorescence in situ Hybridization (FISH)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511060 MDS FISH Panel 510616 Cells Counted 62361-1
511060 MDS FISH Panel 510617 Cells Analyzed 62360-3
511060 MDS FISH Panel 510618 FISH Result 57802-1
511060 MDS FISH Panel 511042 Interpretation 50398-7
511060 MDS FISH Panel 510620 Specimen Type 31208-2
511060 MDS FISH Panel 511038 Director Review: 48672-0

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