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Chromosome Analysis, Chorionic Villi Biopsy With Reflex to SNP Microarray (Reveal®)

Test Number 511033
Test number copied
CPT Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
  • CVS Prenatal Karyotyping, Chromosome Analysis With Reflex to Microarray

Test Details

Methodology

SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.

Result Turnaround Time

9 - 12 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

SNP Microarray Prenatal POC Clinical Questionnaire

Clinical Questionnaire for Prenatal SNP Microarray

Use

The chromosome analysis determines fetal karyotype. A normal chromosome analysis will reflex to the SNP assay, which will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent. If specimens from a twin pregnancy are submitted by request, it can be reported if these are DZ or MZ twins.

Special Instructions

Pertinent medical findings must accompany request.

If prior NIPT studies have been performed, include copy of the report.

Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Chorionic villi

Volume

20 to 30 mg

Minimum Volume

5 mg

Container

The CVS transport tube (a sterile specimen container with transport medium) is available from LabCorp. Please call customer service at 800-345-4363.

Collection Instructions

Specimen is collected in syringe (transabdominal) or catheter (transcervical) and transferred by flushing with the media from the sterile container back into it. After collecting the specimen, wash with sterile saline solution (NaCl 0.95%) containing sodium heparin (two to three drops of sodium heparin in 10 mL of saline). Carefully transfer the specimen into the CVS transport tube, using a sterile Pasteur pipette or a sterile fine-needle forceps. Be sure to fill transport tubes completely with media. Samples from twin (multiple) pregnancies should be appropriately labeled and placed in separate transport containers with a separate test request form for each twin.

Storage Instructions

Maintain specimen at room temperature and transport to the cytogenetics laboratory immediately. Do not freeze. Refrigerate if sterility is questioned or if sample cannot be shipped within 24 hours.

Causes for Rejection

No villi submitted in specimen; improperly labeled specimen; frozen specimen; specimen placed in fixative

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511033 Chromosome CVS RFX CMA 510052 Cells Counted 64089-6
511033 Chromosome CVS RFX CMA 510054 Cells Analyzed 64086-2
511033 Chromosome CVS RFX CMA 510055 Cells Karyotyped 64085-4
511033 Chromosome CVS RFX CMA 510056 GTG Band Resolution 64087-0
511033 Chromosome CVS RFX CMA 510057 Cytogenetic Diagnosis 33774-1
511033 Chromosome CVS RFX CMA 511034 Cytogenetic Interpretation 64088-8
511033 Chromosome CVS RFX CMA 510059 Specimen Type 31208-2
511033 Chromosome CVS RFX CMA 511036 Director Review: 48672-0
511033 Chromosome CVS RFX CMA 052320 Reflex N/A
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510052
Result Code NameCells Counted
UofM
Result LOINC64089-6
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510054
Result Code NameCells Analyzed
UofM
Result LOINC64086-2
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510055
Result Code NameCells Karyotyped
UofM
Result LOINC64085-4
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510056
Result Code NameGTG Band Resolution
UofM
Result LOINC64087-0
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510057
Result Code NameCytogenetic Diagnosis
UofM
Result LOINC33774-1
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code511034
Result Code NameCytogenetic Interpretation
UofM
Result LOINC64088-8
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code510059
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code511036
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code511033
Order Code NameChromosome CVS RFX CMA
Order Loinc
Result Code052320
Result Code NameReflex
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510216 Chromosome Microarray N/A
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510216
Result NameChromosome Microarray
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510043 Specimen Type 31208-2
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510043
Result NameSpecimen Type
UofM
Result LOINC31208-2
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510044 # of Genotyping Targets N/A
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510044
Result Name# of Genotyping Targets
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510045 Array Type N/A
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510045
Result NameArray Type
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510048 Diagnosis 48000-4
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510048
Result NameDiagnosis
UofM
Result LOINC48000-4
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510049 Interpretation 50398-7
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510049
Result NameInterpretation
UofM
Result LOINC50398-7
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 510061 Director Review 48672-0
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code510061
Result NameDirector Review
UofM
Result LOINC48672-0
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 510098 Chromosome Microarray 512123 PDF 11502-2
Reflex 1
Order Code510098
Order NameChromosome Microarray
Result Code512123
Result NamePDF
UofM
Result LOINC11502-2