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CHOP Oncology FISH

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  • Leukemia FISH
  • Lymphoma FISH

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Expected Turnaround Time

4 - 7 days

Specimen Requirements


Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.


Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow


Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube


Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Test Details


Confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas)


Fluorescence in situ hybridization (FISH)

Additional Information

The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510349 CHOP Oncology FISH 510520 Specimen Type 31208-2
510349 CHOP Oncology FISH 510521 Cells Counted n/a
510349 CHOP Oncology FISH 510522 Cells Analyzed n/a
510349 CHOP Oncology FISH 510351 FISH Result 48674-6
510349 CHOP Oncology FISH 510526 Interpretation 50398-7
510349 CHOP Oncology FISH 510352 Director Review: 48672-0
510349 CHOP Oncology FISH 512123 PDF 51967-8

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