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SNP Microarray−Oncology (Reveal®)

CPT: 81277
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  • Reveal® Microarray

Special Instructions

Pertinent medical findings should accompany the test request form.

Expected Turnaround Time

10 - 14 days

Specimen Requirements


Whole blood, bone marrow, or nonfixed tumor tissue


4 mL whole blood, 2 mL bone marrow, or >2 to 4 mm3 tissue

Minimum Volume

2 mL whole blood or 1 mL bone marrow for array only (Note: This volume does not allow for repeat testing.)


Green-top (heparin) tube (preferred), yellow-top (ACD) tube, or lavender-top (EDTA) tube; sterile container containing sterile saline, Ringer's lactate, or Hanks' balanced salt solution or transport medium provided by the cytogenetic laboratory

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets

Test Details


This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.


This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.


Gunnarsson R, Staaf J, Jansson M, et al. Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia−A comparative study of four differently designed, high resolution microarray platforms. Genes Chromosomes Cancer. 2008 Aug; 47(8):697-711.18484635


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510146 Reveal (R) SNP CMA - Oncology 510139 Specimen Type 31208-2
510146 Reveal (R) SNP CMA - Oncology 510147 # of Genotyping Targets n/a
510146 Reveal (R) SNP CMA - Oncology 510218 Diagnosis 62357-9
510146 Reveal (R) SNP CMA - Oncology 510159 Interpretation 62365-2
510146 Reveal (R) SNP CMA - Oncology 510161 Director Review: 48672-0
510146 Reveal (R) SNP CMA - Oncology 512123 PDF 51967-8

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