LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.
8 - 12 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
For more information, please view the literature below.
Red-top or gel-barrier tube
Frozen preferred, refrigerate acceptable
Aid in the diagnosis of rheumatoid arthritis (RA)1,2
Results of this panel should be used in conjunction with clinical findings and other laboratory tests.
"It is acknowledged that an individual patient may meet the definition of RA without requiring that all tests be performed. For example, patients with a sufficient number of joints involved and longer duration of symptoms will meet criteria regardless of their serologic or acute-phase response status. The classification criteria can be applied to any patient or otherwise healthy individual, as long as 2 mandatory requirements are met: First, there must be evidence of currently active clinical synovitis (i.e., swelling) in at least 1 joint as determined by an expert assessor. Second, the criteria may be applied only to those patients in whom the observed synovitis is not better explained by another diagnosis."6
RA Factor: Immunoturbidimetry
CCP Antibodies: ELISA
14-3-3 eta protein: ELISA
• RA Factor:<14 IU/mL
• CCP Antibodies IgG, IgA: Units
Weak positive: 20 - 39
Moderate positive: 40 - 59
Strong positive: >59
• 14-3-3 eta protein: <0.2 ng/mL
This RheumAssure panel is comprised of three tests: RA Factor, CCP Antibodies, and 14-3-3 eta protein.
Used together, these three markers are able to diagnose established RA with a sensitivity of 88-96% and early RA with a sensitivity of 78- 92%.1,2
RA factor (also called RF) is elevated in established RA (sensitivity 72-85%)2,3 and in early RA (sensitivity 44-63%).1,4 Its specificity for RA is 80%.3
CCP Antibodies have similar sensitivities for established RA (66-79%) and early RA (59%)2,3 but higher specificity (90-96%).3,5
Serum 14-3-3 eta protein is elevated in both established RA (sensitivity 77%) and early RA (sensitivity 59-64%).1,2 It may provide a 15-20% incremental benefit in identifying early RA.1,4
Therefore, elevation of one or more markers of RheumAssure is consistent with a diagnosis of rheumatoid arthritis. When all three markers are negative, an RA diagnosis is less likely.
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