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Heart Disease and Stroke Risk Profile

CPT: 83695; 85246; 85384; 86141
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Test Includes

C-reactive protein, cardiac; fibrinogen activity; lipoprotein (a); von Willebrand factor antigen


Special Instructions

State patient's sex on the request form. If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.


Expected Turnaround Time

2 - 5 days


Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium


    Specimen Requirements


    Specimen

    Serum and plasma, frozen


    Volume

    1 mL serum and 1 mL frozen plasma


    Container

    Red-top tube or gel-barrier tube and blue-top (sodium citrate) tube or lavender-top (EDTA) tube


    Collection

    Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device (ie, "butterfly"), in which case a discard tube should be used.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

    Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.


    Storage Instructions

    Refrigerate serum. Freeze plasma.


    Patient Preparation

    Do not draw from an arm with a heparin lock or heparinized catheter.


    Test Details


    Methodology

    See individual tests.


    Footnotes

    1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
    2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
    3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
    4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
    5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    500140 Heart Disease/Stroke Risk 120190 Lipoprotein (a) nmol/L 43583-4
    500140 Heart Disease/Stroke Risk 120768 C-Reactive Protein, Cardiac mg/L 30522-7
    500140 Heart Disease/Stroke Risk 001702 Fibrinogen Activity mg/dL 3255-7
    500140 Heart Disease/Stroke Risk 086280 von Willebrand Factor (vWF) Ag % 27816-8

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