ATN Profile

CPT: 83520(x4)
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  • Alzheimer's

Test Includes

Beta Amyloid 42/40 Ratio; Phosphorylated Tau 181 (pTau-181); Neurofilament Light Chain (NfL)

Special Instructions

This test currently is not available in New York state.

Expected Turnaround Time

7 - 10 days

Related Documents

Specimen Requirements


Plasma, frozen


3 mL

Minimum Volume

2.5 mL (Note: This volume does not allow for repeat testing.)


Lavender-top (EDTA) tube, screw-capped frozen transport tube


Draw blood into an EDTA tube. Separate plasma from blood via centrifugation (>1500 g for 10 minutes) within 40 minutes after blood collection. Transfer EDTA to a Labcorp polypropylene transport tube and seal.

Plasma samples may be stored for up to six hours at 2°C to 8°C prior to placing in dry ice (for shipment) or an ultra-low freezer transfer (< -60°C).

Do not freeze samples at -20°C; analyte stability is not preserved.

Storage Instructions


Stability Requirements



Room temperature

Unstable (stability provided by manufacturer or literature reference)


Unstable (stability provided by manufacturer or literature reference)


14 days (stability provided by manufacturer or literature reference)

Test Details


This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer's disease pathology.


These tests were developed and their performance characteristics determined by Labcorp. They have not been cleared or approved by the Food and Drug Administration.


Sysmex chemiluminescence enzyme immunoassay (CLEIA) and Roche Diagnostics electrochemiluminescence immunoassay (ECLIA)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
484400 ATN Profile 484403 A -- Beta-amyloid 42/40 Ratio Pending
484400 ATN Profile 484406 Beta-amyloid 42 pg/ml Pending
484400 ATN Profile 484408 Beta-amyloid 40 pg/ml Pending
484400 ATN Profile 484404 T -- p-tau181 pg/mL Pending
484400 ATN Profile 484405 N -- NfL, Plasma pg/mL 101281-4
484400 ATN Profile 484119 ATN SUMMARY[1] N/A
484400 ATN Profile 484407 Information: N/A
Reflex Table for ATN SUMMARY[1]
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 484401 ATN SUMMARY[1] 484401 ATN SUMMARY[1] Pending

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at