Synonyms
- Alzheimer's
Test Includes
Beta Amyloid 42/40 Ratio; Phosphorylated Tau 181 (pTau-181); Neurofilament Light Chain (NfL)
Special Instructions
This test currently is not available in New York state.
Expected Turnaround Time
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Plasma, frozen
Volume
3 mL
Minimum Volume
2.5 mL (Note: This volume does not allow for repeat testing.)
Container
Lavender-top (EDTA) tube, screw-capped frozen transport tube
Collection
Draw blood into an EDTA tube. Separate plasma from blood via centrifugation (>1500 g for 10 minutes) within 40 minutes after blood collection. Transfer EDTA to a Labcorp polypropylene transport tube and seal.
Plasma samples may be stored for up to six hours at 2°C to 8°C prior to placing in dry ice (for shipment) or an ultra-low freezer transfer (< -60°C).
Do not freeze samples at -20°C; analyte stability is not preserved.
Storage Instructions
Freeze.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | Unstable (stability provided by manufacturer or literature reference) |
Refrigerated | Unstable (stability provided by manufacturer or literature reference) |
Frozen | 14 days (stability provided by manufacturer or literature reference) |
Test Details
Use
This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer's disease pathology.
Limitations
These tests were developed and their performance characteristics determined by Labcorp. They have not been cleared or approved by the Food and Drug Administration.
Methodology
Sysmex chemiluminescence enzyme immunoassay (CLEIA) and Roche Diagnostics electrochemiluminescence immunoassay (ECLIA)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 484400 | ATN Profile | 484403 | A -- Beta-amyloid 42/40 Ratio | Pending | ||
| 484400 | ATN Profile | 484406 | Beta-amyloid 42 | pg/ml | Pending | |
| 484400 | ATN Profile | 484408 | Beta-amyloid 40 | pg/ml | Pending | |
| 484400 | ATN Profile | 484404 | T -- p-tau181 | pg/mL | Pending | |
| 484400 | ATN Profile | 484405 | N -- NfL, Plasma | pg/mL | 101281-4 | |
| 484400 | ATN Profile | 484119 | ATN SUMMARY[1] | N/A | ||
| 484400 | ATN Profile | 484407 | Information: | N/A |
| Reflex Table for ATN SUMMARY[1] | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 484401 | ATN SUMMARY[1] | 484401 | ATN SUMMARY[1] | Pending | |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf