Testing will be delayed if the pathology report is not received. Fixation time and fixative used must be indicated on the test requisition form.
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Formalin fixed paraffin-embedded (FFPE) tissue block or slides
One paraffin block or seven unstained, positively charged tissue slides cut at 4-5 microns
Five unstained slides
Paraffin block transport pouch or slide mailer
Specimen should be fixed in a 10% neutral-buffered formalin. Cold ischemic time should be less than one hour and fixation time should be between six and 72 hours.
Maintain specimen at room temperature.
Tumor type other than colorectal cancer (CRC); fixative other than neutral buffered formalin; insufficient tumor cellularity
HER2 is a known negative predictive biomarker in colorectal cancer (CRC). Recent trials have established HER2 as a therapeutic target in CRC. This assay assists in determining eligibility for HER2 therapy in patients with CRC.
Use of fixatives other than 10% formalin may not yield reliable results.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|484007||HER2 IHC RFX FISH, CRC||484328||HER-2/neu (C-erbB-2)||Pending|
|484007||HER2 IHC RFX FISH, CRC||484330||Scoring Guide||Pending|
|484007||HER2 IHC RFX FISH, CRC||484331||Comment||Pending|
|484007||HER2 IHC RFX FISH, CRC||484332||Fixation Time||Pending|
|484007||HER2 IHC RFX FISH, CRC||484333||Fixative||Pending|
|484007||HER2 IHC RFX FISH, CRC||484325||Director Review||Pending|
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