GeneSeq® PLUS

CPT: Contact CPT coding department at 800-222-7566, ext. 6-8400.
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  • Full gene sequencing, partner testing
  • gene specific sequencing

Test Includes

This test includes all genes included in any Inheritest® or GeneSeq®: Cardio panel except SMN1 and FMR1.

Special Instructions

The specific gene(s) to be analyzed must be indicated on the test requisition form. Failure to indicate the gene(s) will result in testing delays. Variants of uncertain significance (VUS) will be reported unless VUS opt out is indicated on the requisition.

Test orders must include an attestation that the provider has the patient's informed consent for genetic testing.

Expected Turnaround Time

14 - 21 days (In some cases, additional time may be required for confirmatory or reflex tests.)

Specimen Requirements


Whole blood or PurFlock buccal swab kit or Oragene Dx 500 saliva kit


8.5 mL whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit

Minimum Volume

3 mL whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit


Yellow-top (ACD-A) tube or lavender-top (EDTA) tube or PurFlock buccal swab kit or Oragene Dx 500 saliva collection kit


Standard phlebotomyl follow PurFlock buccal swab kit or Oragene Dx 500 saliva kit collection instructions. Do not eat, drink, smoke, or chew gum 30 minutes prior to collection.

Storage Instructions

Maintain specimen at room temperature or refrigerate at 4°C. Do not freeze.

Stability Requirements

Whole blood: 14 days at room temperature or 30 days at 4°C

Buccal: 60 days at room temperature

Saliva: 60 days at room temperature

Causes for Rejection

Frozen or hemolyzed specimen; quantity not sufficient for analysis; improper container

Test Details


Single gene analysis is available for all genes included in any Inheritest® or GeneSeq®: Cardio panel except for SMN1 and FMR1. To order single gene analysis, use Spinal Muscular Atrophy (SMA) [481630] and Fragile X Syndrome, Carrier [481684].


Technologies used do not detect germline mosaicism and do not rule out the presence of large chromosomal aberrations including rearrangements and gene fusions, or variants in regions or genes not included in this test, or possible inter/intragenic interactions between variants or repeat expansions.

Variant classification and/or interpretation may change over time if more information becomes available. False positive or false negative results may occur for reasons that include: rare genetic variants, sex chromosome abnormalities, pseudogene interference, blood transfusions, bone marrow transplantation, somatic or tissue-specific mosaicism, mislabeled samples or erroneous representation of family relationships.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Next Generation Sequencing: Identifies genetic variants, including small nucleotide variants (SNVs), insertions, deletions and copy number variants (CNVs).


Rehder C, Bean LJH, Bick D, et al. Next-generation sequencing for constitutional variants in the clinical laboratory, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021 Aug;23(8):1399-1415.33927380
Richards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015 May;17(5):405-424.25741868


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
482370 GeneSeq PLUS 482354 Test Detail 19102-3
482370 GeneSeq PLUS 482355 Ethnicity 42784-9
482370 GeneSeq PLUS 482356 Specimen Type 31208-2
482370 GeneSeq PLUS 482357 Genetic Counselor 89993-0
482370 GeneSeq PLUS 482358 Indication 42349-1
482370 GeneSeq PLUS 482359 Result: 50397-9
482370 GeneSeq PLUS 482360 Interpretation 53039-4
482370 GeneSeq PLUS 482361 General Comments 8262-8
482370 GeneSeq PLUS 482362 Recommendations 62385-0
482370 GeneSeq PLUS 482363 Additional ClinicalInformation 55752-0
482370 GeneSeq PLUS 482364 Comments 8251-1
482370 GeneSeq PLUS 482365 Methods/Limitations 49549-9
482370 GeneSeq PLUS 482366 References 75608-0
482370 GeneSeq PLUS 482367 Director Review/Release 72486-4
482370 GeneSeq PLUS 482368 PDF 51969-4

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