Please direct any questions regarding this test to customer service at 800-345-4363.
5 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Whole blood, bone marrow, formalin-fixed, paraffin-embedded (FFPE) tissue block or slides, fresh or frozen tissue
3 to 5 mL whole blood, 1 to 2 mL bone marrow, five unstained slides at 10 µM or formalin-fixed, paraffin-embedded tissue block, tissue in RPMI or frozen
0.5 mL whole blood or 0.5 mL bone marrow, two unstained slides at 10 µM
Lavender-top (EDTA) tube, yellow-top (ACD) tube, green-top (heparin) tube, FFPE tissue block or slides, or tissue in RPMI or frozen
Fresh tissue should be placed in RPMI medium or shipped frozen on dry ice. Small samples (eg, punch biopsies, fine-needle aspirates) will also be accepted. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate specimens for each test requested.
Maintain whole blood, bone marrow or tissue in RPMI at 2°C to 8°C; FFPE specimens at room temperature; frozen tissue at -80°C.
Frozen whole blood/bone marrow; quantity not sufficient for analysis; tumor block containing no tumor tissue; broken or stained slides
This assay can be used to detect clonal immunoglobulin receptor kappa-chain gene rearrangements in blood, bone marrow, and tissue specimens with combined B-cell clonality detection rate of 94% to 99%. The presence of a monoclonal gene rearrangement usually, but not always, reflects the presence of a T-lymphocytic neoplasm, while polyclonal gene rearrangement patterns are found in benign reactive conditions. Thus, the results of these studies can assist in the diagnosis of lymphoproliferative disorders.
This PCR assay is able to detect a clonal DNA population at the sensitivity of 5% in a background of polyclonal DNA.
This test was developed, and its performance characteristics determined, by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Polymerase chain reaction (PCR)
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|480812||IgK Gene Rearrangement, PCR||480813||IgK PCR Interpretation||21748-9|
|480812||IgK Gene Rearrangement, PCR||480828||K Clonal Size||n/a|
|480812||IgK Gene Rearrangement, PCR||480777||Block Number:||n/a|
|480812||IgK Gene Rearrangement, PCR||489028||Director Review||72486-4|
|480812||IgK Gene Rearrangement, PCR||480831||Methodology:||49549-9|
|480812||IgK Gene Rearrangement, PCR||480842||References:||n/a|
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf