Test Details
Methodology
Immunohistochemistry (IHC)
Result Turnaround Time
2 - 4 days
|
2 - 4 days |
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
HER-2-positive carcinomas predict response to humanized monoclonal antibody trastuzumab (Herceptin®) in conjunction with chemotherapy in patients with advanced or metastatic gastric or gastro-esphageal junction carcinoma.
Special Instructions
Please direct any questions regarding this test to oncology customer service at 800-345-4363. Please note: fixation time and fixative used must be indicated on the test request form.
Limitations
Use of fixatives other than 10% formalin, fixation times less than six hours or greater than 48 hours may not yield reliable results.
Specimen Requirements
Specimen
Tumor (formalin-fixed, paraffin-embedded)
Volume
One paraffin block or five unstained, positively charged tissue slides cut at 4 to 5 microns and dried for one hour at 60°C.
Container
Paraffin block transport pouch or slide mailer
Collection Instructions
FFPE tissue, preserved in 10% neutral buffered formalin, fixed for 18 to 24 hours. ASCO/CAP 2013 guidelines recommend fixation time between six and 72 hours for breast tissue; however, special ASCO/CAP guidelines have not been established for gastric cancer samples.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Tumor other than gastric tumor
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 480423 | HER-2/neu (C-erbB-2) | 18474-7 | ||
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 480424 | Scoring Guide | N/A | ||
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 480374 | Comment | 77202-0 | ||
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 483318 | Fixation Time | N/A | ||
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 483319 | Fixative | N/A | ||
| 480226 | HER-2/neu IHC,Gastric,Paraffin | 480232 | Director Review | 69426-5 | ||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 480423 | |||||
| Result Code Name | HER-2/neu (C-erbB-2) | |||||
| UofM | ||||||
| Result LOINC | 18474-7 | |||||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 480424 | |||||
| Result Code Name | Scoring Guide | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 480374 | |||||
| Result Code Name | Comment | |||||
| UofM | ||||||
| Result LOINC | 77202-0 | |||||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 483318 | |||||
| Result Code Name | Fixation Time | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 483319 | |||||
| Result Code Name | Fixative | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 480226 | |||||
| Order Code Name | HER-2/neu IHC,Gastric,Paraffin | |||||
| Order Loinc | ||||||
| Result Code | 480232 | |||||
| Result Code Name | Director Review | |||||
| UofM | ||||||
| Result LOINC | 69426-5 |