Thrombosis, Venous Risk Profile

CPT: 81240; 81241; 85300; 85303; 85306; 85379; 85598; 85610; 85613; 85670; 85730; 86146(x3); 86147(x2). If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Includes

Anticardiolipin antibodies, IgG and IgM; antithrombin activity; β2-glycoprotein 1 antibodies, IgA, IgG, and IgM; D-dimer; dRVVT screen; factor II (prothrombin) mutation analysis; factor V Leiden mutation analysis; protein C, functional; protein S antigen, free


Expected Turnaround Time

4 - 10 days



Related Documents


Specimen Requirements


Specimen

Plasma, frozen and serum, refrigerated, and whole blood or buccal swab kit (Buccal swab collection kit contains instructions for the use of a buccal swab.)


Volume

6 mL frozen plasma (3 mL in each of two tubes) and 2 mL serum and 7 mL whole blood or LabCorp buccal swab kit


Minimum Volume

3 mL frozen plasma and 0.5 mL serum and 3 mL whole blood or two buccal swabs


Container

Blue-top (sodium citrate) tube, gel-barrier tube, lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit


Collection

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.


Storage Instructions

Freeze plasma. Refrigerate serum. Maintain whole blood and buccal swab kit at room temperature or refrigerate.


Patient Preparation

Do not draw from an arm with a heparin lock or heparinized catheter.


Test Details


Methodology

See individual tests.


Footnotes

1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing.Am J Clin Pathol. 1997; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, et al. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997; 107(6):681-683. 9169665
5.McGlasson DL, More L, Best HA, et al. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999; 12(3):137-139. 10539100

References

Alving BM. The antiphospholipid syndrome: Clinical presentation, diagnosis, and patient management. In: Kitchens CS, Alving BM, Kessler CM, eds. Consultative Hemostasis and Thrombosis. Philadelphia, Pa: WB Saunders Co; 2002:181-196.
Baglin T, Gray E, Greaves M, et al. Clinical Guidelines for testing heritable thrombophilia. Br J Haem. 2010; 149:209-220.
Schafer AI, Levine MN, Konkle BA, Kearon C. Thrombotic disorders: Diagnosis and treatment. Hematology (Am Soc Hematol Educ Program). 2003; 520-539. 14633797
Triplett DA. Thrombophilia. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Philadelphia, Pa: Lippincott Williams and Wilkins;2002:1033-1049.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
385730 Thrombosis, Venous Risk 115206 D-Dimer mg/L FEU 48065-7
385730 Thrombosis, Venous Risk 015040 Antithrombin Activity % 27811-9
385730 Thrombosis, Venous Risk 117705 Protein C-Functional % 27819-2
385730 Thrombosis, Venous Risk 164519 Protein S, Free % 27821-8
385730 Thrombosis, Venous Risk 117012 aPTT sec 14979-9
385730 Thrombosis, Venous Risk 117030 PT sec 5902-2
385730 Thrombosis, Venous Risk 115108 INR 6301-6
385730 Thrombosis, Venous Risk 109009 Thrombin Time sec 3243-3
385730 Thrombosis, Venous Risk 117891 dRVVT sec 6303-2
385730 Thrombosis, Venous Risk 117842 Hexagonal Phase Phospholipid sec 3282-1
385730 Thrombosis, Venous Risk 161812 Anticardiolipin Ab,IgG,Qn GPL U/mL 3181-5
385730 Thrombosis, Venous Risk 161830 Anticardiolipin Ab,IgM,Qn MPL U/mL 3182-3
385730 Thrombosis, Venous Risk 163881 Beta-2 Glycoprotein I Ab, IgG GPI IgG units 16135-6
385730 Thrombosis, Venous Risk 163907 Beta-2 Glycoprotein I Ab, IgM GPI IgM units 16136-4
385730 Thrombosis, Venous Risk 117080 APS Panel Interpretation 50595-8
385730 Thrombosis, Venous Risk 163899 Beta-2 Glycoprotein I Ab, IgA GPI IgA units 21108-6
385730 Thrombosis, Venous Risk 511559 Factor V Leiden Mutation 21667-1
Reflex Table for aPTT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117159 aPTT 1:1 Normal Plasma 117159 aPTT 1:1 Normal Plasma sec 5946-9
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117203 Thrombin Neutralization 117203 Thrombin Neutralization sec 46224-2
Reflex Table for dRVVT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117924 dRVVT Confirm 117924 dRVVT Confirm ratio 50410-0

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