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Cryptococcus Antigen

CPT: 87899. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Includes

Reflex to titer on positive result

Expected Turnaround Time

2 - 3 days

Related Information

Related Documents

Specimen Requirements




2 mL

Minimum Volume

0.5 mL

Storage Instructions

Refrigerated (2°-8°C) or frozen (<−20°C)

Stability Requirements




72 hours (stability provided by manufacturer or literature reference)


>72 hours (stability provided by manufacturer or literature reference)

Causes for Rejection

Quantity not sufficient for analysis; inappropriate specimen source; inappropriate specimen collection device; hemolysis; lipemia; specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the test request form

Test Details


Aid in establishing the presence of Cryptococcus neoformans or Cryptococcus gattii infection


Endpoint titers may not correlate between different methods of cryptococcal antigen testing. Patients with positive cryptococcal antigen results, therefore, should be monitored using the same assay.


Lateral flow immunochromographic assay

Additional Information

Published data for the median sensitivity and specificity for serum specimens are 100% and 99.5%, respectively. False-positive results due to the presence of rheumatoid factor have not been noted with the cryptococcal antigen lateral flow immunochromatographic assay. A negative test does not preclude diagnosis of Cryptococcus infection, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis.


Binnicker MJ, Jespersen DJ, Bestrom JE, Rollins LO. Comparison of four assays for the detection of cryptococcal antigen. Clin Vaccine Immunol. 2012 Dec; 19(12):1988-1990. 23081814
Klausner JD, Vijayan T, Chiller T. Sensitivity and specificity of a new cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid.MLO. 2013 Mar; 45(3):16,18,20. 23822028


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
183025 Cryptococcus Antigen, Serum 70910-5 183026 Cryptococcus Antigen, Serum 70910-5
Reflex Table for Cryptococcus Antigen, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 183036 Cryptococcus Ag Titer, Serum 183036 Cryptococcus Ag Titer, Serum 9818-6

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