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Cryptococcus Antigen

CPT: 87899. If reflex testing is performed, concomitant CPT codes/charges will apply.
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Test Includes

Reflex to titer on positive result


Expected Turnaround Time

2 - 3 days


Related Information


Related Documents


Specimen Requirements


Specimen

Serum


Volume

2 mL


Minimum Volume

0.5 mL


Storage Instructions

Refrigerated (2°-8°C) or frozen (<−20°C)


Stability Requirements

Temperature

Period

Refrigerated

72 hours (stability provided by manufacturer or literature reference)

Frozen

>72 hours (stability provided by manufacturer or literature reference)


Causes for Rejection

Quantity not sufficient for analysis; inappropriate specimen source; inappropriate specimen collection device; hemolysis; lipemia; specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the test request form


Test Details


Use

Aid in establishing the presence of Cryptococcus neoformans or Cryptococcus gattii infection


Limitations

Endpoint titers may not correlate between different methods of cryptococcal antigen testing. Patients with positive cryptococcal antigen results, therefore, should be monitored using the same assay.


Methodology

Lateral flow immunochromographic assay


Additional Information

Published data for the median sensitivity and specificity for serum specimens are 100% and 99.5%, respectively. False-positive results due to the presence of rheumatoid factor have not been noted with the cryptococcal antigen lateral flow immunochromatographic assay. A negative test does not preclude diagnosis of Cryptococcus infection, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis.


References

Binnicker MJ, Jespersen DJ, Bestrom JE, Rollins LO. Comparison of four assays for the detection of cryptococcal antigen. Clin Vaccine Immunol. 2012 Dec; 19(12):1988-1990. 23081814
Klausner JD, Vijayan T, Chiller T. Sensitivity and specificity of a new cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid.MLO. 2013 Mar; 45(3):16,18,20. 23822028

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
183025 Cryptococcus Antigen, Serum 70910-5 183026 Cryptococcus Antigen, Serum 70910-5
Reflex Table for Cryptococcus Antigen, Serum
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 183036 Cryptococcus Ag Titer, Serum 183036 Cryptococcus Ag Titer, Serum 9818-6

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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf