Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Gel-barrier tube, red-top tube
Draw blood in gel-barrier tube and centrifuge. If red-top tube is used, centrifuge within 45 minutes of draw, remove the serum, place in a plastic transport tube and tightly stopper the tube.
Refrigerated or frozen
The presence of anti-centromere antibodies (ACA) is predictive of the development of Systemic Sclerosis (SSc) in either apparently health individuals or in patients with Connective Tissue Disease (CTD).1 ACA is found in approximately 30% of patients with SSc and has a distribution range of 11% to 40% worldwide with greater frequency in Caucasians than Asians or African-Americans.2 ACA is recognized as one of the serological markers of limited SSc with features of long lasting Raynaud's disease and subsequent development of progressive thickening of skin at the extremities, neck and face.1 About 10% to 20% of ACA-positive patients develop pulmonary arterial hypertension.3 ACA has been found to be associated with anti-Ro/SSA (both Ro-52 and Ro-60) in approximately 30% of SSc patients.3 Patients with SSc who are also positive for ACA and anti-mitochondrial antibodies have a higher rate of primary biliary cirrhosis.4
This test detects the presence of anti-centromere-A (CENP-A) and anti-centromere-B (CENP-B) antibodies and reports total anti-centromere antibodies in units without differentiating between anti-CENP-A and anti-CENP-B.
For the detection of other forms of anti-centromere antibodies, please note that there is another test number for Anti-Centromere Ab by IFA (indirect fluorescence/immunofluorescence assay) where total antibodies are reported as a titer.
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|169500||Anti-Centromere Ab by EIA||169501||Anti-Centromere Ab by EIA||Units||Pending|
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