Coxsackie A Virus Antibody Profile, IgG, IgM

CPT: 86658(x8)
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  • Hand, Foot, and Mouth Disease

Expected Turnaround Time

1 - 5 days

Related Documents

Specimen Requirements




1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Gel-barrier tube or red-top tube

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Microbially-contaminated or heat-treated specimen; specimen containing particulate matter; grossly hemolyzed, lipemic, or icteric samples

Test Details


This assay uses indirect immunofluorescence to determine IgG and IgM titers to Coxsackie A serotypes A7, A9, A16, and A24. Recent infections of Coxsackie viruses are characterized by elevated titers of IgG and IgM.


A positive test result does not necessarily indicate current or recent infection as antibodies to Coxsackie species can be detected in uninfected individuals due to moderate passive exposure to infected hosts. It is, therefore, crucial that results from all Coxsackie A serologies correlate with the clinical history of the patient and all other data available to the physician. Samples collected at the early stage of infection (primarily in children) may not yield detectable antibodies. If a recent infection is suspected, a second specimen should be collected 10 to 20 days following the initial collection and tested.


Indirect fluorescent antibody (IFA)

Additional Information

Coxsackie viruses are enteroviruses belonging to the Picornavirus family, which is comprised of strains A and B as well as various serotypes A1-22, 24, and B1-6. Following incubation, a variety of well known diseases can manifest themselves within the host. Coxsackie A is commonly associated with hand, foot, and mouth disease, which primarily affects children younger than 10 years of age. In rare cases, Coxsackie infections may produce mild or subclinical symptoms, yet most infections trigger the onset of flu-like ailments but may include symptoms of other diseases along the lines of pneumonia, hepatitis, and meningitis.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
163295 Coxsackie A IgG/IgM Antibody 163276 Coxsackie A7 IgG titer 59584-3
163295 Coxsackie A IgG/IgM Antibody 163277 Coxsackie A9 IgG titer 58792-3
163295 Coxsackie A IgG/IgM Antibody 163278 Coxsackie A16 IgG titer 59583-5
163295 Coxsackie A IgG/IgM Antibody 163279 Coxsackie A24 IgG titer 59582-7
163295 Coxsackie A IgG/IgM Antibody 163291 Coxsackie A7 IgM titer 59581-9
163295 Coxsackie A IgG/IgM Antibody 163292 Coxsackie A9 IgM titer 58791-5
163295 Coxsackie A IgG/IgM Antibody 163293 Coxsackie A16 IgM titer 59580-1
163295 Coxsackie A IgG/IgM Antibody 163294 Coxsackie A24 IgM titer 59579-3

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