Human Herpesvirus 6 (HHV-6) Antibodies, IgG

CPT: 86790
Print Share


  • HHV-6, IgG Antibodies

Expected Turnaround Time

2 - 6 days

Related Documents

Specimen Requirements




1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Red-top tube or gel-barrier tube


Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x4

Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination

Test Details


Aid in the diagnosis of past infection/exposure to roseola infantum; may be useful in diagnosis of chronic fatigue syndrome


This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.


Enzyme immunoassay (EIA)

Reference Interval

• Negative: <0.90 index

• Equivocal: 0.90−1.10 index

• Positive: >1.10 index

Fourfold rises in titer are suggestive of either recent, primary, or reactivated infection. The presence of elevated titers to HHV-6 in the absence of responses to HAV, HBV, CMV, and EMV suggests that titer results are associated with high specificity.

Additional Information

Human herpesvirus 6 (HHV-6) has recently been identified as the agent associated with both pediatric and adult infections. Most children have been infected by age three. The acute infection in children is characterized clinically by an acute febrile illness, irritability, inflammation of tympanic membranes, and (uncommonly) a rash characteristic of roseola.

In adults, HHV-6 has been associated with chronic fatigue and spontaneously resolving fever resembling a mononucleosis-like illness. During the acute episode an elevated IgM HHV-6 is useful. An increase in IgG HHV-6 between acute and convalescent serum sample is consistent with a recent HHV-6 infection.


Huang LM, Lee CY, Lin KH, et al. Human herpesvirus-6 associated with fatal haemophagocytic syndrome. Lancet. 1990 Jul 7; 336(8706):60-61. (letter) 1973248
Suga S, Yoshikawa T, Asano Y, Yazaki T, Hirata S. Human herpesvirus-6 infection (exanthem subitum) without rash. Pediatrics. 1989 Jun; 83(6):1003-1006. 2542875
Wakefield D, Lloyd A, Dwyer J, Salahuddin SZ, Ablashi DV. Human herpesvirus-6 and myalgic encephalomyelitis. Lancet. 1988 May 7; 1(8593):1059. 2896906
Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet. 1988 May 14; 1(8594):1065-1067. 2896909


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
161075 HHV 6 IgG Antibodies 41148-8 161076 HHV 6 IgG Antibodies index 41148-8

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at