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Hepatitis B Surface Antigen (HBsAg). Specimens positive for HBsAg reflex to Hepatitis Be Antigen (HBeAg), Hepatitis Be Antibody (anti-HBe), HBV Quantitative DNA, and ALT.
If reflex test is performed, additional charges/CPT code(s) may apply.
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
1 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Serum or EDTA plasma
9.5 mL (2.5 mL for HBV DNA)
3.6 mL (0.7 mL for HBV DNA)
Gel-barrier tube, red top tube, or lavender-top (EDTA) tube
Two samples must be submitted.
All tests except DNA: If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
HBV DNA: Centrifuge sample within 24 hours of collection. Transfer serum/plasma to a screw-cap polypropylene transport tube. Ship frozen (preferred). Plasma from a PPT can be frozen in situ.
To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit a separate frozen specimen for each test requested.
All tests except DNA: Refrigerated (preferred) up to 7 days. Frozen up to 14 days. Room temperature up to 7 days.
HBV DNA: Frozen (preferred) up to 12 weeks. Refrigerated up to 6 days. Room temperature up to 24 hours.
Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluid other than serum or EDTA plasma; gross hemolysis; excessive lipemia; improper labeling
This panel is intended for use in the management of patients with chronic hepatitis B and to assess the efficacy of antiviral treatment. A positive HBsAg test will reflex to HBeAg, anti-HBe, HBV quantitative DNA, and ALT.
Anti-HBe: Assay performance characteristics have not been established for testing of children less than 17 years of age or pregnant women or in immunocompromized or immunosuppressed patients.
The HBV quantitative real-time PCR assay has a quantitative range of 10 to 1,000,000,000 IU/mL.
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