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NT-proBNP

CPT: 83880
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Synonyms

  • proBNP
  • Propeptide of Brain Natriuretic Peptide

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.


Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Serum (preferred) or plasma


Volume

0.8 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube, gel-barrier tube, green-top (lithium heparin), or lavender-top (EDTA) tube


Collection

If a red-top tube or plasma is used, separate serum or plasma to a plastic transport tube.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

3 days

Refrigerated

6 days

Frozen

24 months

Freeze/thaw cycles

Stable x1


Causes for Rejection

Citrate plasma specimen; grossly hemolyzed samples; improper labeling


Test Details


Use

Support a diagnosis of congestive heart failure (CHF)


Methodology

Electrochemiluminescence immunoassay (ECLIA)


Reference Interval

See table.

Age

Male (pg/mL)

Female (pg/mL)

0 to 11 m

Not established

Not established

1 to 3 y

0−320

0−320

4 to 6 y

0−190

0−190

7 to 9 y

0−145

0−145

10 y

0−112

0−112

11 y

0−317

0−317

12 y

0−186

0−186

13 y

0−370

0−370

14 y

0−363

0−363

15 y

0−217

0−217

16 y

0−206

0−206

17 y

0−135

0−135

18 y

0−115

0−115

19 to 44 y

0−86

0−130

45 to 54 y

0−121

0−249

55 to 64 y

0−210

0−287

65 to 74 y

0−376

0−301

>74 y

0−486

0−738


References

Januzzi JL Jr, Chen-Tournoux AA, Moe G. Amino-terminal pro-B-type natriuretic peptide testing for the diagnosis or exclusion of heart failure in patients with acute symptoms. Am J Cardiol. 2008 Feb 4; 101(3A):29-38. 18243855
proBNP on Elecys 1010/2010 and Modular Analytics E170 [package insert]. 2007-07, V 46. Indianapolis, Ind: Roche Diagnostics; 2007.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
143000 NT-proBNP 33762-6 143001 NT-proBNP pg/mL 33762-6

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf