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Interleukin-10, Serum

CPT: 83520

Synonyms

  • IL-10
  • IL10

Expected Turnaround Time

4 - 7 days



Related Documents


Specimen Requirements


Specimen

Serum


Volume

0.5 mL


Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

Separate serum from cells. Transfer serum to a plastic transport tube.


Storage Instructions

Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles x3.


Causes for Rejection

Gross hemolysis; sample left on cells


Test Details


Use

Interleukin-10 (IL-10) is an important suppressor of immune responses.1-3 In vitro studies indicate that IL-10 directly inhibits IL-2 and IL-5 production by TH1 and TH2 cells. IL-10 acts as an immunosuppressor of antigen presenting cells (APC). IL-10 suppresses epidermal Langerhans cell APC function, monocyte chemokines expression, and the bactericidal responses of macrophages. A number of studies suggest that IL-10 plays a role in controlling inflammation, autoimmunity, and angiogenesis.


Limitations

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


Footnotes

1. Ding UZ, Fu S, Zamarin D, et al. Interleukin-10. In: Thomson AW, Lotze MT eds. Cytokine Handbook. 4th ed, vol 1. London, UK, and San Diego, Calif: Academic Press, Elsevier Science;2003:603-625.
2. Mosser DM, Zhang X. Interleukin-10: New perspectives on an old cytokine. Immunol Rev. 2008 Dec; 226:205-218. 19161426
3. Hedrich CM, Bream JH. Cell type-specific regulation of IL-10 expression In inflammation and disease. Immunol Res. 2010 Jul; 47(1-3):185-206. 20087682

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