Human Herpesvirus 6 (HHV-6), IgM

CPT: 86790
Print Share

Synonyms

  • HHV-6 IgM Antibody

Expected Turnaround Time

1 - 6 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Storage Instructions

Refrigerate


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

The detection of anti-HHV-6 IgM or a fourfold rise in anti-HHV-6 IgG supports a clinical diagnosis of HHV-6 infection. Human IgM antibodies to HHV-6 antigens are detected by indirect fluorescent antibody (IFA) assay. Diluted serum is incubated on a slide containing infected T-lymphoblasts. If specific HHV-6 antibodies are present, they remain bound, are then labeled by an antibody conjugate and finally detected by fluorescence microscopy.

Human Herpesvirus-6 (HHV-6) is a distinct herpes virus that typically causes a self-limiting illness in patients who are not immunocompromised. In some patients, especially if immunocompromised, HHV-6 can cause febrile convulsions in infants, encephalitis mononucleosis-like symptoms, and hepatitis.


Limitations

IgM antibody only appears during an active infection or for 2-3 months after an active infection. However, the absence of an IgM antibody does not mean the patient does not have an active infection. Chronic infections in various tissues can persist with no evidence of IgM.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Immunofluorescence (IF)


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
138529 Human Herpes Virus Type 6 IgM 25417-7 139587 Human Herpes Virus Type 6 IgM 25417-7

For Providers

Please login to order a test

Order a Test

© 2023 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2023, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf