|
|
Babesia IgG; Babesia, IgM
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Serum
1 mL
0.2 mL
Red-top tube or gel-barrier tube or serum transfer tube
Red-top tube or gel-barrier tube |
Red-top tube or gel-barrier tube or serum transfer tube |
Refrigerate.
Refrigerate |
Refrigerate. |
Extensive hemolysis; lipemia; clotted specimen; quantity not sufficient for analysis; leaking or broken tube
This test is a screening assay for Babesia microti infection or exposure.
Serological testing for antibodies to Babesia microti (B. microti) can provide evidence to support a diagnosis of babesiosis. Serology should not be used for routine diagnosis of acute babesiosis, as it is difficult to distinguish active from past infection using serology alone. A B. microti IgG antibody titer of greater than or equal to 1:1024 or the presence of B. microti IgM antibody are suggestive of active or recent B. microti infection, while a 4-fold rise in Babesia IgG antibody in sera from the time of acute illness to the time of convalescence confirms the diagnosis. Individuals positive for B. microti antibodies should have confirmatory testing performed by PCR or peripheral blood smear before treatment is considered. The diagnosis of acute babesiosis cannot be confirmed solely by the presence of Babesia antibody in a serum sample collected at a single time point. Babesiosis coinfection should be considered in Lyme disease patients with severe illness, in those whose symptoms are unlikely to be explained by B. burgdorferi infection alone, or in those who do not respond well to standard antibiotic therapy for Lyme disease.
|
This test is a screening assay for Babesia microti infection or exposure. Serological testing for antibodies to Babesia microti (B. microti) can provide evidence to support a diagnosis of babesiosis. Serology should not be used for routine diagnosis of acute babesiosis, as it is difficult to distinguish active from past infection using serology alone. A B. microti IgG antibody titer of greater than or equal to 1:1024 or the presence of B. microti IgM antibody are suggestive of active or recent B. microti infection, while a 4-fold rise in Babesia IgG antibody in sera from the time of acute illness to the time of convalescence confirms the diagnosis. Individuals positive for B. microti antibodies should have confirmatory testing performed by PCR or peripheral blood smear before treatment is considered. The diagnosis of acute babesiosis cannot be confirmed solely by the presence of Babesia antibody in a serum sample collected at a single time point. Babesiosis coinfection should be considered in Lyme disease patients with severe illness, in those whose symptoms are unlikely to be explained by B. burgdorferi infection alone, or in those who do not respond well to standard antibiotic therapy for Lyme disease. |
The diagnosis of acute babesiosis cannot be confirmed solely by the presence of Babesia antibody in a serum sample collected at a single time point. Antibody detection by serologic testing can provide supportive evidence for the diagnosis of babesiosis but does not reliably distinguish between active and prior infection.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
|
The diagnosis of acute babesiosis cannot be confirmed solely by the presence of Babesia antibody in a serum sample collected at a single time point. Antibody detection by serologic testing can provide supportive evidence for the diagnosis of babesiosis but does not reliably distinguish between active and prior infection. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. |
Immunofluorescence assay (IFA)
Krause PJ, Telford SR 3rd, Ryan R, et al. Diagnosis of babesiosis: Evaluation of a serologic test for the detection of Babesia microti antibody. J Infect Dis. 1994 Apr; 169(4):923-926. 8133112 |
Centers for Disease Control and Prevention (CDC). Tickborne Diseases of the United States: A reference manual for healthcare providers. Sixth edition. 2022. CDC website: https://www.cdc.gov/ticks/tickbornediseases/index.html. Accessed May 2023. Krause PJ, Auwaerter PG, Bannuru RR, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clin Infect Dis. 2021 Jan 27;72(2) 72(2):185-189.33501959 |
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
138315 | Babesia microti Antibody Panel | 88728-1 | 138316 | Babesia microti IgG | 9584-4 | |
138315 | Babesia microti Antibody Panel | 88728-1 | 138317 | Babesia microti IgM | 9585-1 |
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf