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Porphyrins, Quantitative, Random Urine

CPT: 84120
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Synonyms

  • Coproporphyrin
  • Uroporphyrin

Test Includes

Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins; hexacarboxylporphyrins; pentacarboxylporphyrins


Expected Turnaround Time

3 - 5 days



Related Documents


Specimen Requirements


Specimen

Urine (random); protected from light


Volume

2 mL


Minimum Volume

1.5 mL


Container

12-mL amber plastic transport tube without preservative


Collection

Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp N° 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.


Storage Instructions

Refrigerate and protect from light.


Stability Requirements

Temperature

Period

Room temperature

Unstable

Refrigerated

7 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Stored specimen not refrigerated; specimen exposed to light; acid preservative; pH <3


Test Details


Use

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Quantitative, Random Urine [003053].

For initial evaluation of porphyrias. Use Porphyrins, Quantitative, 24-Hour Urine [003194] to follow up random urine abnormal results.



Methodology

High-pressure liquid chromatography (HPLC) with fluorometric detection


Reference Interval

• Coproporphyrin (CP) I: 0−15 μg/L

• Coproporphyrin (CP) III: 0−49 μg/L

• Heptacarboxylporphyrins (7-CP): 0−2 μg/L

• Hexacarboxylporphyrins (6-CP): 0−1 μg/L

• Pentacarboxylporphyrins (5-CP): 0−2 μg/L

• Uroporphyrins (UP): 0−20 μg/L


Additional Information

Excess urinary porphyrin excretion, or porphyrinuria, results from inhibition of key enzymatic steps in such clinical conditions as genetic deficiencies in heme production enzymes, hepatitis, renal disease, and erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis.1 Both in experimental animals and in humans exposed to heavy metals, elevated levels of porphyrins have been found in urine.1


Footnotes

1. Woods JS. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Can J Physiol Pharmacol. 1996 Feb; 74(2):210-215.8723034

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
120980 Porphyrins, Qn, Random U 120988 Uroporphyrins (UP) ug/L 11228-4
120980 Porphyrins, Qn, Random U 120989 Heptacarboxyl (7-CP) ug/L 2407-5
120980 Porphyrins, Qn, Random U 120990 Hexacarboxyl (6-CP) ug/L 27400-1
120980 Porphyrins, Qn, Random U 120991 Pentacarboxyl (5-CP) ug/L 11221-9
120980 Porphyrins, Qn, Random U 120992 Coproporphyrin (CP) I ug/L 9343-5
120980 Porphyrins, Qn, Random U 120993 Coproporphyrin (CP) III ug/L 9345-0

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