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Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins; hexacarboxylporphyrins; pentacarboxylporphyrins
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Urine (random); protected from light
12-mL amber plastic transport tube without preservative
Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp N° 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.
Refrigerate and protect from light.
Stored specimen not refrigerated; specimen exposed to light; acid preservative; pH <3
Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Quantitative, Random Urine .
For initial evaluation of porphyrias. Use Porphyrins, Quantitative, 24-Hour Urine  to follow up random urine abnormal results.
High-pressure liquid chromatography (HPLC) with fluorometric detection
• Coproporphyrin (CP) I: 0−15 μg/L
• Coproporphyrin (CP) III: 0−49 μg/L
• Heptacarboxylporphyrins (7-CP): 0−2 μg/L
• Hexacarboxylporphyrins (6-CP): 0−1 μg/L
• Pentacarboxylporphyrins (5-CP): 0−2 μg/L
• Uroporphyrins (UP): 0−20 μg/L
Excess urinary porphyrin excretion, or porphyrinuria, results from inhibition of key enzymatic steps in such clinical conditions as genetic deficiencies in heme production enzymes, hepatitis, renal disease, and erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis.1 Both in experimental animals and in humans exposed to heavy metals, elevated levels of porphyrins have been found in urine.1
|Order Code||Order Code Name||Order Loinc||Result Code||Result Code Name||UofM||Result LOINC|
|120980||Porphyrins, Qn, Random U||120988||Uroporphyrins (UP)||ug/L||11228-4|
|120980||Porphyrins, Qn, Random U||120989||Heptacarboxyl (7-CP)||ug/L||2407-5|
|120980||Porphyrins, Qn, Random U||120990||Hexacarboxyl (6-CP)||ug/L||27400-1|
|120980||Porphyrins, Qn, Random U||120991||Pentacarboxyl (5-CP)||ug/L||11221-9|
|120980||Porphyrins, Qn, Random U||120992||Coproporphyrin (CP) I||ug/L||9343-5|
|120980||Porphyrins, Qn, Random U||120993||Coproporphyrin (CP) III||ug/L||9345-0|
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