Reflex to qualitative rapid plasma reagin (RPR) on positives
1 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
For more information, please view the literature below.
Improved Syphilis Reverse Screening Cascade: Earlier Detection With Fewer Ambiguous Results
Serum
1 mL
0.5 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Room temperature
Temperature | Period |
---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Hemolysis; lipemia; gross bacterial contamination; plasma specimen
Serological test for screening for syphilis infection. This panel includes a Treponema-specific test which may be positive in all stages of syphilis. It may be positive with treponemal infections other than syphilis (bejel, pinta, yaws). Like FTA-ABS and TP-PA, once positive, it remains so; it cannot be used to judge the effectiveness of treatment.
The test is not applicable to CSF.
Enzyme immunoassay (EIA) with reflex to charcoal flocculation if reactive
The traditional syphilis screening approach when the first-line test is a nontreponemal assay (like RPR) and if positive, the second-line confirmatory test is a treponemal test (such as TP-PA) was developed many years ago when treponemal tests lacked necessary sensitivity but delivered acceptable specificity. In the early 1990s, the CDC published guidelines that recommended the traditional algorithm for screening. Since that time, a number of new, more sensitive treponemal immunoassays have been introduced. In 2008, the CDC issued a report that describes the new syphilis screening approach in which the treponemal test was used as the first-line test, and if positive, reflexes to the nontreponemal test. This report shows that a number of infected individuals would be missed using the traditional approach. In addition, a number of tested individuals would receive false-positive results.1
The implementation of the new approach−if the highly sensitive and specific treponemal assay is used−allows for an improvement in the early detection of syphilis infection that should lead to more effective treatment while preventing the spread of disease. When the treponemal test is positive, it will reflex to qualitative RPR and, if positive, reflex to RPR titer. If the RPR is negative, it will reflex to another (second) treponemal test for confirmation.
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
082345 | T pallidum Screening Cascade | 47236-5 | 082356 | T pallidum Antibodies | 47236-5 |
Reflex Table for T pallidum Antibodies | ||||||
---|---|---|---|---|---|---|
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
Reflex 1 | 006099 | RPR | 006097 | RPR | 20507-0 | |
Reflex 2 | 006476 | RPR, Quant | 006476 | RPR, Quant | 31147-2 |
Reflex Table for T pallidum Antibodies | ||||||
---|---|---|---|---|---|---|
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
Reflex 1 | 006099 | RPR | 006097 | RPR | 20507-0 | |
Reflex 2 | 163038 | T pallidum Antibody, EIA | 163038 | T pallidum Antibody, EIA | 34147-9 |
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