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Selenium, Whole Blood

CPT: 84255
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Expected Turnaround Time

2 - 4 days


Related Documents


Specimen Requirements


Specimen

Whole blood


Volume

2 mL


Minimum Volume

0.6 mL


Container

Royal blue-top (EDTA) tube; submit original tube.


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Clotted specimen


Test Details


Use

Monitor exposure to selenium; detect selenium deficiency


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)


Additional Information

Selenium toxicity may occur due to industrial exposures or through drinking water in some parts of the world. Toxic symptoms include garlic breath odor, thick brittle fingernails, dry brittle hair, red swollen skin of the hands and feet, and nervous system abnormalities of numbness, convulsions, or paralysis.1 Selenium is produced as a byproduct of copper refining and is used in electronic semiconductors, as a decolorizing agent for ceramics and glass, and as a vulcanizing agent in the rubber industry. The essential nature of selenium in human nutrition is now beyond dispute. Multiple cases of selenium deficiency have been reported in patients receiving parenteral nutrition for longer than one week when no selenium was included in their formula. Deficiency has also been reported in severe malnutrition without parenteral nutrition. The syndrome has included painful weak muscles and acute or chronic congestive heart failure due to cardiomyopathy that is sometimes fatal. Other findings noted in some cases of selenium deficiency include erythrocyte macrocytosis, depigmentation of skin and hair, and elevated transaminase and creatine kinase levels.


Footnotes

1. Jacobs DS, DeMott WR, Oxley DK, eds. Laboratory Test Handbook With Key Word Index. 5th ed. Hudson, Ohio: Lexi-Comp Inc; 2001.

References

Lalonde L, Jean Y, Roberts KD, et al. Fluorometry of selenium in serum or urine. Clin Chem.1982; 28(1):172-174.7055906

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
081034 Selenium, Blood 5722-4 081034 Selenium, Blood ug/L 5722-4

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