Oxycodone and Metabolite

CPT: 80365
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  • Free Oxycodone and Metabolite
  • Oxycontin®
  • Roxicodone®

Expected Turnaround Time

4 - 7 days

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Specimen Requirements


Serum, plasma, or whole blood


0.3 mL

Minimum Volume

0.1 mL


Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.


Separate serum or plasma within one hour of collection and transfer to a plastic transport tube.

Storage Instructions

Refrigerate. Stable at room temperature, refrigerated, or frozen for 14 days.

Causes for Rejection

Gel-barrier tube

Test Details


Opioids is a general term applied to all substances with morphine-like properties and describes naturally occurring or semisynthetic analgesic alkaloids derived from opium. Some important semisynthetic derivatives of morphine include heroin and its metabolite 6-acetyl morphine, oxycodone, codeine, hydrocodone, oxymorphone, dihydrocodeine, and hydromorphone. Opiates are used clinically because of their analgesic properties, also causing sedation, euphoria, respiratory depression, orthostatic hypotension, diminished intestinal motility, nausea, and vomiting. Because of these properties, opioids have a high abuse potential, whereby chronic use leads to tolerance and dependence. Clinical monitoring of compliance is effected through measurement of these analytes.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071538 Oxycodone and Metabolite 071536 Oxycodone ng/mL 3893-5
071538 Oxycodone and Metabolite 071537 Oxymorphone ng/mL 60467-8

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