Chromium, Urine

CPT: 82495; 82570
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Synonyms

  • Cr, Urine

Test Includes

Chromium, urine; creatinine, urine; chromium:creatinine ratio


Special Instructions

Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.


Expected Turnaround Time

2 - 4 days


Related Information


Related Documents


Specimen Requirements


Specimen

Urine (random)


Volume

5 mL


Minimum Volume

0.6 mL


Container

Plastic urine container, no preservative


Collection

Sampling time is during shift or at the end of shift at the end of the work week for industrial exposure monitoring. For metals with multiphase elimination, the timing is given in relation to the work day exposure (shift) as well as to the work week exposure.


Storage Instructions

Maintain specimen at room temperature.


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Test Details


Use

Monitor industrial exposure to chromium


Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Inductively-coupled plasma/mass spectrometry (ICP/MS)


Reference Interval

Occupational exposure: BEI® (sampling time is during shift): 10.0 μg/L;1 BEI® (sampling time is end of shift at the end of the work week): 25.0 μg/L1


Additional Information

Chromium exposure through the inhalation of insoluble chromium compounds may produce pneumoconiosis with impairment of pulmonary function. Exposure to the inorganic soluble salts can precipitate skin ulcerations, dermatitis, perforation of the nasal septum, and respiratory sensitization. Acute exposure to these salts may result in local tissue necrosis and severe kidney damage.2

Chromium and its inorganic salts are widely employed in industry, including metal plating, steel and nonferrous alloys, refractory materials, and chromate pigments and preservatives. In organic forms, chromium is also an essential nutrient for man supplied in the diet (5−115 μg/day); however, overexposure is generally associated with the industrial environment, specifically through the inhalation of chromium dust and fumes.

BEI® are reference values intended as guidelines for evaluation of occupational exposure. BEI® represent biological levels of chemicals that correspond to workers with inhalation exposure equivalent to the threshold limit value (TLV®) of the chemicals. TLVs refer to the airborne concentrations of substances and represent conditions under which it is believed that nearly all workers may be repeatedly exposed, day after day, without adverse health effects.3


Footnotes

1. BEI® (Biological Exposure Indices) based on 2010 Recommendations of the American Conference of Governmental Industrial Hygienists (ACGIH).
2. Baselt RC, Cravey RH. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute;1995.
3. TLVs and BEIs, Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices 2010, American Conference of Governmental Industrial Hygienists (ACGIH).

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
071530 Chromium, Urine 13464-3 071535 Chromium, Urine ug/L 5623-4
071530 Chromium, Urine 13464-3 723280 Creatinine(Crt),U g/L 2161-8
071530 Chromium, Urine 13464-3 071511 Chromium/Creat Ratio ug/g creat 13464-3

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