LabCorp
LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Plasma, frozen
Volume
0.5 mL
Minimum Volume
0.1 mL (Note: This volume does not allow for repeat testing)
Container
Green-top (sodium heparin) tube
Collection
Transfer plasma to a plastic transport tube and freeze. To avoid delays in turnaround time when requesting multiple tests on frozen specimens, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze
Causes for Rejection
Specimen thawed or not frozen; gross hemolysis; specimen type other than frozen plasma
Test Details
Use
Used in the diagnosis and monitoring of inherited disorders of fatty acid oxidation and organic acidurias. May be used as a follow-up test to some abnormal newborn screen results.
Limitations
False-negative results can occur with acylcarnitine profiling, especially when the patient is carnitine deficient, is affected with a milder variant of a disorder, or when clinical condition or dietary supplementation causes secondary changes to the profile. Results of acylcarnitine profiling should be interpreted in the context of clinical presentation as well as other laboratory tests, which may include urine organic acid analysis and molecular testing.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Methodology
Flow injection/tandem mass spectrometry
References
Applied Biosystems. Chemoview Instructions. March 15, 2005.
Bennett M. Laboratory Medicine Practice Guidelines−Follow-up Testing for Metabolic Diseases Identified by Expanded Newborn Screening Using Tandem Mass Spectrometry. Washington DC: AACC Press;2009.
Rinaldo P, Cowan TM, Matern D. Acylcarnitine profile analysis. Genet Med. 2008 Feb; 10(2):151-156.18281923
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 070228 | Acylcarnitine Profile, Plasma | 070081 | C2 | umol/L | 30191-1 | |
| 070228 | Acylcarnitine Profile, Plasma | 070040 | C3 | umol/L | 30551-6 | |
| 070228 | Acylcarnitine Profile, Plasma | 070041 | C3-Dicarboxylic | umol/L | 55940-1 | |
| 070228 | Acylcarnitine Profile, Plasma | 070042 | C4 | umol/L | 51413-3 | |
| 070228 | Acylcarnitine Profile, Plasma | 070043 | C4-Hydroxy | umol/L | 39000-5 | |
| 070228 | Acylcarnitine Profile, Plasma | 070119 | C4-Dicarboxylic | umol/L | 39010-4 | |
| 070228 | Acylcarnitine Profile, Plasma | 070044 | C5 | umol/L | 30531-8 | |
| 070228 | Acylcarnitine Profile, Plasma | 070048 | C5:1 | umol/L | 69573-4 | |
| 070228 | Acylcarnitine Profile, Plasma | 070049 | C5-Hydroxy | umol/L | 51412-5 | |
| 070228 | Acylcarnitine Profile, Plasma | 070051 | C5-Dicarboxylic | umol/L | 30349-5 | |
| 070228 | Acylcarnitine Profile, Plasma | 070057 | C6 | umol/L | 30358-6 | |
| 070228 | Acylcarnitine Profile, Plasma | 070058 | C8 | umol/L | 30540-9 | |
| 070228 | Acylcarnitine Profile, Plasma | 070059 | C10 | umol/L | 30327-1 | |
| 070228 | Acylcarnitine Profile, Plasma | 070061 | C10:1 | umol/L | 30328-9 | |
| 070228 | Acylcarnitine Profile, Plasma | 070062 | C10:2 | umol/L | 53471-9 | |
| 070228 | Acylcarnitine Profile, Plasma | 070063 | C12 | umol/L | 30331-3 | |
| 070228 | Acylcarnitine Profile, Plasma | 070064 | C14 | umol/L | 30565-6 | |
| 070228 | Acylcarnitine Profile, Plasma | 070065 | C14:1 | umol/L | 30566-4 | |
| 070228 | Acylcarnitine Profile, Plasma | 070066 | C14:2 | umol/L | 30564-9 | |
| 070228 | Acylcarnitine Profile, Plasma | 070067 | C14-Hydroxy | umol/L | 30238-0 | |
| 070228 | Acylcarnitine Profile, Plasma | 070068 | C16 | umol/L | 30356-0 | |
| 070228 | Acylcarnitine Profile, Plasma | 070069 | C16:1 | umol/L | 30357-8 | |
| 070228 | Acylcarnitine Profile, Plasma | 070070 | C16:1-Hydroxy | umol/L | 30235-6 | |
| 070228 | Acylcarnitine Profile, Plasma | 070071 | C16-Hydroxy | umol/L | 30234-9 | |
| 070228 | Acylcarnitine Profile, Plasma | 070072 | C18 | umol/L | 30560-7 | |
| 070228 | Acylcarnitine Profile, Plasma | 070073 | C18:1 | umol/L | 30542-5 | |
| 070228 | Acylcarnitine Profile, Plasma | 070074 | C18:2 | umol/L | 30534-2 | |
| 070228 | Acylcarnitine Profile, Plasma | 070075 | C18-Hydroxy | umol/L | 35656-8 | |
| 070228 | Acylcarnitine Profile, Plasma | 070076 | C18:1-Hydroxy | umol/L | 30312-3 | |
| 070228 | Acylcarnitine Profile, Plasma | 070077 | C18:2-Hydroxy | umol/L | 30237-2 | |
| 070228 | Acylcarnitine Profile, Plasma | 070082 | Interpretation | 46252-3 | ||
| 070228 | Acylcarnitine Profile, Plasma | 070079 | Director Review | 72486-4 | ||
| 070228 | Acylcarnitine Profile, Plasma | 070080 | Methodology | 49549-9 | ||
| 070228 | Acylcarnitine Profile, Plasma | 700471 | Disclaimer: | N/A |
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