LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.

Hepatitis B Core Antibody, IgM

CPT: 86705
Print Share


  • Anti-HBc, IgM
  • Antibody to Hepatitis B Core Antigen, IgM

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Expected Turnaround Time

1 - 2 days

Related Documents

Specimen Requirements


Serum or plasma


1 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube


If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tubes

Test Details


IgM antibody to hepatitis B core antigen is a reliable marker for acute disease for a hepatitis B viral infection. At times this marker is the only one demonstrated for the diagnosis of a hepatitis B viral infection.


Immunochemiluminometric assay (ICMA)

Reference Interval


Additional Information

Anti-HBc appears 5 to 14 days after HBe antigen and can be found shortly before HBsAg is no longer detectable. It may be negative in 9% of patients with acute hepatitis B in the first two weeks of illness, and should be repeated if clinically warranted. Anti-HBc and anti-HBe may be the only markers detectable in some patients at the time of presentation. The period between the disappearance of HBsAg and the appearance of HBsAb is often called the “core window.” Anti-HBc persists for months to years after resolution of acute hepatitis B, and also persists in cases of chronic infection; however, the demonstration of IgM-specific HBcAb is evidence that the patient is in an acute infection. Conversely, the absence of IgM core antibody in a patient with long-term B surface antigenemia suggests chronic hepatitis B viral infection. In addition, the absence of IgM core antibody with persistent B surface antigen and symptoms of acute hepatitis suggests acute non-A, non-B hepatitis or superinfection with δ hepatitis. See figure.


AuBuchon JP, Sandler SG, Fang CT, Dodd RY. American Red Cross experience with routine testing for hepatitis B core antibody. Transfusion. 1989 Mar-Apr; 29(3):230-232. 2493695
Chambers LA, Popovsky MA. Decrease in reported posttransfusion hepatitis. Contributions of donor screening for alanine aminotransferase and antibodies to hepatitis B core antigen and changes in the general population. Arch Intern Med. 1991 Dec; 151(12):2445-2448. 1747001
Edwards MS. Hepatitis B serology--help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515. 3287312
Gupta S, Govindarajan S, Fong TL, Redeker AG. Spontaneous reactivation in chronic hepatitis B: patterns and natural history. J Clin Gastroenterol. 1990 Oct; 12(5):562-568. 2230000
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757 (review). 3319367
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. 7315794


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
016881 Hep B Core Ab, IgM 24113-3 016881 Hep B Core Ab, IgM 24113-3

For Providers

Please login to order a test

Order a Test

© 2020 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at Additional information regarding LOINC® codes can be found at, including the LOINC Manual, which can be downloaded at