Immunoglobulin G, Quantitative, Cerebrospinal Fluid

CPT: 82784
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  • Cerebrospinal Fluid IgG
  • CSF IgG
  • CSF Immunoglobulin G
  • IgG, CSF
  • IgG, Quantitative, CSF
  • Immunoglobulin G, CSF

Test Includes

Quantitation of CSF IgG

Special Instructions

The third tube of a routinely obtained three-tube set of CSF should be used for CSF IgG study.

Expected Turnaround Time

3 - 5 days

Related Documents

Specimen Requirements


Cerebrospinal fluid (CSF)


0.5 mL

Minimum Volume

0.25 mL


Sterile container

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Excessive blood in CSF

Test Details


Evaluate central nervous system involvement by infection, neoplasm, or primary neurologic disease (in particular, multiple sclerosis)


Normal levels do not exclude disease; clinical correlation must be applied.



Reference Interval

See table.


Male (mg/dL)

Female (mg/dL)

0 to 1 y

Not established

Not established

2 to 12 y



13 to 17 y



>17 y



Additional Information

Cerebrospinal fluid protein is elevated in many conditions which affect the central nervous system primarily or secondarily. In inflammatory or destructive processes in which serum leaks into CSF, both IgG and albumin will be present in the CSF in increased amounts. Since albumin is not, but immunoglobulins are, synthesized in the central nervous system, a relative increase in CSF IgG indicates presence of a process involving the central nervous system primarily, in particular multiple sclerosis.

IgG showed marked elevation (>16 mg/dL) in 36% of MS patients with only 1% of non-MS controls having this degree of increase. In the slightly elevated category (11% to 16%) however, there was considerable overlap with 38% of MS patients and 27% of non-MS patients falling into this category. While MS patients are maintained on ACTH and/or steroid therapy or during remission, CSF IgG levels decrease but generally remain significantly elevated.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
012211 Immunoglobulin G, Quant, CSF 2464-6 012212 IgG, Quant, CSF mg/dL 2464-6

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