α-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida

CPT: 82105
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Synonyms

  • AFP, Maternal Serum
  • Alpha-Fetoprotein (AFP), Maternal Serum for Open Spina Bifida
  • Maternal Serum α-Fetoprotein
  • msAFP

Special Instructions

This test screens for open spina bifida. This test does not screen for Down syndrome or trisomy 18. The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's weight, patient's date of birth, patient's race (white, black, other), and insulin-dependent diabetic status. Also indicate relevant patient history, such as prior neural tube defects, ultrasound anomalies, or previous maternal serum screening during this pregnancy. Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening request form (0900). Specimens must be collected before amniocentesis.

Open spina bifida screening is offered for gestational ages 15.0 to 23.9 weeks. The optimal gestational age for open spina bifida screening is 16.0 to 18.9 weeks.


Expected Turnaround Time

2 - 5 days


Related Documents


Specimen Requirements


Specimen

Serum


Volume

3 mL


Minimum Volume

0.5 mL


Container

Gel-barrier tube


Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type


Test Details


Use

Screening test for open neural tube defects. Detects 80% of open spina bifida and 90% of anencephaly. Please note that this test does not provide screening for Down syndrome or trisomy 18.


Limitations

MS-AFP is a screening test. This test does not screen for Down syndrome or trisomy 18. A positive result means that more diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

Chemiluminescent immunoassay


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
010801 AFP, Serum, Open Spina Bifida 48802-3 017004 Results N/A
010801 AFP, Serum, Open Spina Bifida 48802-3 017961 Gest. Age on Collection Date weeks 18185-9
010801 AFP, Serum, Open Spina Bifida 48802-3 017991 Maternal Age At EDD yr 43993-5
010801 AFP, Serum, Open Spina Bifida 48802-3 017993 Weight lbs 29463-7
010801 AFP, Serum, Open Spina Bifida 48802-3 017995 Multiple Gestation 45371-2
010801 AFP, Serum, Open Spina Bifida 48802-3 017965 AFP MoM 20450-3
010801 AFP, Serum, Open Spina Bifida 48802-3 018006 Interpretation 49246-2
010801 AFP, Serum, Open Spina Bifida 48802-3 511933 PDF 11502-2

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