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HLA B*57:01, Abacavir Hypersensitivity HLA Association Test

CPT: 81381
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  • Abacavir Hypersensitivity HLA Association
  • B*5701
  • B*57:01
  • B5701
  • HLA Antigen B*57:01
  • HLA B*5701
  • HLA B57
  • HLA B5701
  • Hypersensitivity

Special Instructions

If you have questions, please telephone 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.

Expected Turnaround Time

3 - 7 days

Related Documents

Specimen Requirements


Whole blood or buccal swabs


7 mL whole blood or four buccal swabs

Minimum Volume

3 mL whole blood or four buccal swabs


Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal swab kit, please telephone 800-533-1037.

Storage Instructions

Maintain blood specimen at room temperature. Keep buccal swabs dry and at room temperature.

Causes for Rejection

Hemolysis; clotted specimen; insufficient amount of DNA on buccal swabs

Test Details


Determine the presence of B57 antigen


Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for testing.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).


Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSOP)

This is a class I allele-specific test.

Additional Information

Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response. The presence of the HLA-B*57:01 allele increases the susceptibility to abacavir hypersensitivity in several populations studied.


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006926 HLA B5701 Test 42358-2 006930 Result 42358-2

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