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Synonyms
- Anti-HAV, IgM
- Antibody to Hepatitis A Virus, IgM
- HAVAb, IgM
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum or plasma
Volume
1 mL
Minimum Volume
0.4 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
Collection
If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Non-EDTA plasma specimen; PST gel-barrier tube
Test Details
Use
Differential diagnosis of hepatitis; the presence of IgM antibody to hepatitis A virus is good evidence for acute hepatitis A.
Methodology
Immunochemiluminometric assay (ICMA)
Reference Interval
Negative
Additional Information
Hepatitis A virus is a picornavirus, and antibody is made to capsid proteins. Fecal excretion of HAV peaks before symptoms develop. If hepatitis A antibody is IgM, the hepatitis A infection is probably acute. IgM antibody develops within a week of symptom onset, peaks in three months, and is usually gone after six months. Hepatitis A antibody of IgG type is indicative of old infection, is found in almost 50% of adults, and is not usually clinically relevant. Many cases of hepatitis A are subclinical, particularly in children. Presence of IgG antibody to HAV does not exclude acute hepatitis B or other forms of hepatitis.
References
Giacoia GP, Kasprisin DO. Transfusion-acquired hepatitis A. South Med J. 1989; 82(11):1357-1360. 2683125
Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987; 7(4):741-757 (review). 3319367
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006734 | Hep A Ab, IgM | 13950-1 | 006734 | Hep A Ab, IgM | 13950-1 |
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