Hepatitis A Virus (HAV) Antibody, Total

CPT: 86708
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  • anti-HAV
  • Antibody to Hepatitis A Virus
  • HAV

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Expected Turnaround Time

1 - 2 days

Related Documents

Specimen Requirements


Serum or plasma


1 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Red-top tube, gel-barrier tube or lavender-top (EDTA) tube


If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube. Do not freeze gel-barrier tube (pour off serum first).

Storage Instructions

Room temperature

Stability Requirements



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tube; grossly hemolyzed specimens

Test Details


This assay is used to detect total antibodies (IgG and IgM) against Hepatitis A virus (HAV) and may be helpful when assessing HAV immunity. The detection of total antibodies cannot differentiate between vaccination, previously resolved infection, or active infection. If active hepatitis A infection is suspected, HAV IgM testing should be performed. Hepatitis A is a vaccine-preventable disease of the liver caused by the Hepatitis A virus (HAV). HAV is transmitted via the fecal-oral route, usually from direct person-to-person contact or consumption of contaminated food or water. Hepatitis A is an acute, self-limited disease that does not result in chronic infection. HAV IgG antibodies produced in response to vaccination and/or HAV infection persist for life and protect against reinfection.


This assay has not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed individuals. This assay does not differentiate IgG and IgM.


Immunochemiluminometric assay (ICMA)

Reference Interval


Additional Information

See table.

HAV antibody testing interpretation chart

HAV Total Antibody




Not done

No evidence of vaccination or previous infection;

Susceptible to Hepatitis A infection


Not done

Consistent with recent or remote Hepatitis A infection or antibody response to HAV vaccination



Consistent with resolved Hepatitis A infection or antibody response to HAV vaccination



Consistent with active Hepatitis A infection


Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnisis of infectios diseases: 2018 update by the Infectious Disease Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):813-816.30169655
Nelson NP, Wenk MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.32614811


Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006726 Hep A Ab, Total 13951-9 006726 Hep A Ab, Total 13951-9

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