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Hepatitis Be Antibody

CPT: 86707
Updated on 09/27/2020
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Synonyms

  • Anti-HBe
  • Antibody to Hepatitis Be Antigen
  • HBeAb

Expected Turnaround Time

1 - 5 days


Related Documents


Specimen Requirements


Specimen

Serum or plasma


Volume

1 mL


Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube


Collection

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.


Storage Instructions

Room temperature

Refrigerate.

Room temperature


Stability Requirements

Temperature

Period

Room Temperature

7 days (stability provided by manufacturer or literature reference)

Refrigerated

7 days (stability provided by manufacturer or literature reference)

Frozen

14 days (stability provided by manufacturer or literature reference)

Freeze/thaw cycles

Stable x3 (stability provided by manufacturer or literature reference)

Temperature

Period

Room Temperature

7 days (stability provided by manufacturer or literature reference)

Refrigerated

7 days (stability provided by manufacturer or literature reference)

Frozen

14 days (stability provided by manufacturer or literature reference)

Freeze/thaw cycles

Stable x3 (stability provided by manufacturer or literature reference)


Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tube


Test Details


Use

The presence of antibody to hepatitis Be antigen (anti-HBe) can be used in conjunction with other serological and clinical information to determine the stage and prognosis of hepatitis B infection.

Differential diagnosis, staging, and prognosis of hepatitis B infection

The presence of antibody to hepatitis Be antigen (anti-HBe) can be used in conjunction with other serological and clinical information to determine the stage and prognosis of hepatitis B infection.


Methodology

Enzyme immunoassay (EIA)


Reference Interval

Negative


Additional Information

The appearance of anti-HBe in patients who have previously been HBeAg positive indicates a reduced risk of infectivity. Failure of appearance implies disease activity and probable chronicity but patients with HBeAb may have chronic hepatitis. Chronic HBsAg carriers can be positive for either HBeAg or anti-HBe, but are less infectious when anti-HBe is present. HBe can persist for years, but usually disappears earlier than anti-HBs or anti-HBc. Anti-HBe has not been found as the sole serologic marker for hepatitis B infection.


References

Abara WE, Qaseem A, Schillie S, et al. Hepatitis B Vaccination, Screening, and Likage to Care: Best Practice Advice from American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2017 Dec 5;167(11):794-804.29159414
Schillie S, Vellozzi C, Reingold A, et al. Prevention of Hepatitis B Virus Infection in the United States. Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018 Jan 12;67(1):1-31.29939980
Terrault NA, Lok ASF, McMahon BJ, et al. Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology. 2018 Apr;67(4):1560-1599.29405329
Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.26042815
Bortolotti F, Calzia R, Cadrobbi P, Crivellaro C, Alberti A, Marazzi MG. Long-term evolution of chronic hepatitis B in children with antibody to hepatitis B e antigen. J Pediatr. 1990 Apr; 116(4):552-555. 2319401
Edwards MS. Hepatitis B serology−help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). 3287312
Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. 7315794
Mushahwar IK, McGrath LC, Drnec J, Overby LR. Radioimmunoassay for detection of hepatitis B e antigen and its antibody. Results of clinical evaluation. Am J Clin Pathol. 1981 Nov; 76(5):692-697. 6170222
Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1; 294(14):746-749. 943694
Abara WE, Qaseem A, Schillie S, et al. Hepatitis B Vaccination, Screening, and Likage to Care: Best Practice Advice from American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2017 Dec 5;167(11):794-804.29159414
Schillie S, Vellozzi C, Reingold A, et al. Prevention of Hepatitis B Virus Infection in the United States. Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018 Jan 12;67(1):1-31.29939980
Terrault NA, Lok ASF, McMahon BJ, et al. Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology. 2018 Apr;67(4):1560-1599.29405329
Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.26042815

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006635 Hep Be Ab 13953-5 006635 Hep Be Ab 13953-5

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