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Antiparietal Cell Antibody (APCA)

CPT: 83516
Updated on 01/29/2020
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Synonyms

  • Gastric Parietal Cell Antibodies

Test Includes

Titer

Titer


Expected Turnaround Time

1 - 4 days


Related Information


Related Documents


Specimen Requirements


Specimen

Serum


Volume

1 mL


Minimum Volume

0.3 mL


Container

Red-top tube or gel-barrier tube


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added


Test Details


Use

Detection of gastric parietal cell antibodies of the IgG class in human sera. Autoantibodies to gastric parietal cells are found in approximately 90% of patients with pernicious anemia and in about 30% of first degree relatives of patients with pernicious anemia. Increased levels of gastric parietal cells have been found in patients with thyroid disease, iron deficiency anemia, alopecia areata, and vitiligo.


Limitations

The presence of immune complexes in a patient's sample may cause an elevated level of nonspecific binding and produce false-positive results. Assay performance has not been established for pediatric patients.


Methodology

Enzyme-linked immunosorbent assay (ELISA)


Reference Interval

• Negative: 0.0−20.0

• Equivocal: 20.1−24.9

• Positive: >24.9


LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006486 Antiparietal Cell Antibody 8087-9 006487 Antiparietal Cell Antibody Units 8087-9

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