LabCorp
LabCorp and its Specialty Testing Group, a fully integrated portfolio of specialty and esoteric testing laboratories.
Synonyms
- E1
Special Instructions
Nonpregnant patients only.
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum or plasma
Volume
0.8 mL
Minimum Volume
0.4 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube
Collection
If a red-top tube or lavender-top tube is used, transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Refrigerate
Patient Preparation
No isotopes administered 24 hours prior to venipuncture.
Causes for Rejection
Gross hemolysis; recently administered radioisotopes; lipemia; icteric specimen
Test Details
Use
Evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.
Methodology
Radioimmunoassay (RIA)
Reference Interval
See table.1-2
Age (y) | Male (pg/mL) | Female (pg/mL) |
|---|---|---|
Tanner Stage I | 5−17 | 4−29 |
Tanner Stage II | 10−25 | 10−33 |
Tanner Stage III | 15−25 | 15−43 |
Tanner Stage IV | 15−45 | 16−77 |
Tanner Stage V | 20−45 | 29−105 |
Adults | 15−65 | Follicular phase: 39−132 |
Periovulatory: 58−256 | ||
Luteal phase: 54−179 | ||
Pregnancy | ||
1st trimester: 247−2774 | ||
2nd trimester: 569−5781 | ||
Postmenopausal | ||
with ERT: 51−488 | ||
without ERT: 31−100 |
Footnotes
1. Tietz NW, ed. Clinical Guide to Laboratory Tests. 4th ed. Philadelphia, Pa: WB Saunders Co; 2006:378-379.
2. Estrone RIA DSL8700-FOC-02 [package insert]. Beckman Coulter/ImmunoTech; 2018.
References
Kronenberg H, Williams HR. The physiology and pathology of the female reporductive axis. In: Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders/Elsevier; 2008:541-614.
Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med. 2002 Jan 31;346(5):340-352.11821512
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 004564 | Estrone, Serum | 2258-2 | 004564 | Estrone, Serum | pg/mL | 2258-2 |
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