Test Details
Methodology
Enzyme immunoassay (EIA)
Result Turnaround Time
4 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used to evaluate postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.
Special Instructions
Nonpregnant patients only.
Footnotes
References
Custom Additional Information
Estrone (E1) is a steroid, a weak estrogen, and a minor female sex hormone.3,4 Estrone is one of three major endogenous estrogens, the others being estradiol and estriol.3,4 Like the other estrogens, estrone is synthesized from cholesterol and secreted mainly from the gonads, though they can also be formed from adrenal androgens in adipose tissue. Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to estrone, leading to higher concentrations. Estrone can be converted into estradiol and serves mainly as a precursor or metabolic intermediate of estradiol. In addition, an increase in the ratio of estrone to estradiol may be useful in assessing menopause in women.
Specimen Requirements
Specimen
Serum from a serum separator tube
Volume
0.6 mL
Minimum Volume
0.4 mL (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier serum separator tube; red top tubes (without gel barrier) should not be used
Stability Requirements
Temperature | Period |
---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
See table.
Age (y) | Male (pg/mL)1,2 | Female (pg/mL)1,2 |
---|---|---|
Tanner Stage I | 5−17 | 4−29 |
Tanner Stage II | 10−25 | 10−33 |
Tanner Stage III | 15−25 | 15−43 |
Tanner Stage IV | 15−45 | 16−77 |
Tanner Stage V | 20−45 | 29−105 |
Adults | 0−174 | Adult (Premenopausal): 27−231 |
Menstrual Cycle (1-10 days): 19−149 | ||
Menstrual Cycle (11-20 days): 32−176 | ||
Menstrual Cycle (21-30 days): 37−200 | ||
Adult (Postmenopausal): 0−125 |
Storage Instructions
Room temperature
Causes for Rejection
Sample collected with any tube other than a gel barrier (serum separator) tube; hemolysis
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
004564 | Estrone, Serum | 2258-2 | 004564 | Estrone, Serum | pg/mL | 2258-2 |
Order Code | 004564 | |||||
Order Code Name | Estrone, Serum | |||||
Order Loinc | 2258-2 | |||||
Result Code | 004564 | |||||
Result Code Name | Estrone, Serum | |||||
UofM | pg/mL | |||||
Result LOINC | 2258-2 |